【Npe】

Cov khoom xyaw tseem ceeb:Akkermansia muciniphilaAK 47, maltodextrin

【Kev muaj peev xwm】

Hom	Code	Specification
Pasteurized AKK	UA 47	Ntau dua lossis sib npaug rau 1.0 × 10¹¹cell/g
Allergen dawb pasteurized AKK	AK 47 F UA	Ntau dua lossis sib npaug rau 1.0 × 10¹¹cell/g

【Source】

Cov kab mob no tau raug cais tawm ntawm cov quav tib neeg noj qab haus huv

【Storage thiab txee lub neej】

Cov pasteurized akk tuaj yeem khaws cia rau hauv qhov chaw txias thiab qhuav, lub txee lub neej yog 24 lub hlis.

【Packaging】

Lub hnab sab hauv ntawm cov khoom yog ib lub hnab PE self-sealing, thiab txheej txheej yog ib lub hnab ntim cov ntawv nplaum uas muaj qhov kub thiab txias. Cov ntawv ntim khoom tau muab faib ua 500g / hnab, 1kg / hnab, 5kg / hnab, lossis raws li cov neeg siv khoom xav tau.

【Kev nyab xeeb thiab zoo】

Lub freeze-dried probiotic hmoov yog tsim nyob rau hauv raws li GMP tus qauv thiab ua raws li cov kev cai, cov cai thiab cov kev cai nyob rau hauv Suav teb.

【Non-GMO】

Tsis muaj kev tshuaj ntsuam genetic engineering, mutagenesis lossis gene manipulation tau ua tiav ntawm hom kab mob no. Rau qhov zoo tshaj plaws ntawm peb cov kev paub, cov khoom no tsis yog muab los ntawm lossis tsim siv GMOs lossis lawv cov khoom siv, thiab txhua yam tsim nyog tau ua kom tsis txhob muaj kab mob los ntawm GMO lossis lawv cov derivatives.

Kev ua haujlwm

Tiv thaiv atherosclerosis

①Txoj kev raug mob endothelial cell

Endothelial dysfunction yog ib qho tseem ceeb ntawm kev pheej hmoo rau cov kab mob plawv thiab yog thawj kauj ruam hauv kev tsim cov kab mob atherosclerosis. Oxidized low-density lipoprotein (ox-LDL) yog ib qho tseem ceeb ntawm cov kab mob endothelial cell raug mob thiab koom nrog kev puas tsuaj ntawm tes nrog rau qhov tshwm sim thiab kev loj hlob ntawm cov kab mob atherosclerotic. Hauv qhov kev sim no, ox-LDL-induced HAEC cell (tib neeg aortic endothelial cell) raug mob qauv raug siv los txiav txim qhov cuam tshuam ntawm cov tshuaj sib txawv ntawm inactivated AK47 (tsawg koob 10.⁵cell / ml, siab 10⁶cell / mL) ntawm HAEC cell viability, lactate dehydrogenase (LDH) tso tawm, thiab cov qib reactive oxygen hom (ROS). Cov txiaj ntsig kev sim tau pom hauv daim duab hauv qab no:

Cov txiaj ntsig tau qhia tias daim ntawv thov ntawm AK47, nyob rau hauv ntau qhov sib txawv, tsis ua rau muaj kev cuam tshuam tshwj xeeb rau kev ua haujlwm ntawm tes.

Endothelial cell dysfunction, apoptosis, los yog necrosis uas ua rau kev puas tsuaj ntawm cell membrane qauv tuaj yeem ua rau tso tawm lactate dehydrogenase (LDH) los ntawm cytoplasm mus rau hauv kab lis kev cai nruab nrab. Yog li ntawd, LDH tso tawm yog suav tias yog ib qho kev qhia tseem ceeb rau kev kuaj xyuas kev ncaj ncees ntawm tes. Cov txiaj ntsig kev sim tau pom tias tom qab kev kho mob nrog ox-LDL rau 24 teev, LDH tso tawm los ntawm HAEC hlwb tau txhim kho zoo dua piv rau pawg tswj hwm. Txawm li cas los xij, kev kho mob nrog cov koob tshuaj sib txawv ntawm AK47 tau thim rov qab qhov nce hauv intracellular LDH tso tawm los ntawm oxidized low-density lipoprotein, qhia tias HH-AKK1 muaj kev tiv thaiv ntawm cell membrane qauv thiab tuaj yeem cuam tshuam qhov tawm ntawm cov tshuaj intracellular.

Reactive Oxygen Species (ROS) yog cov cim tseem ceeb ntawm kev puas tsuaj ntawm cellular oxidative thiab cuam tshuam nrog ntau yam kab mob plawv. Qhov kev sim tau pom tias piv rau cov pab pawg tswj hwm lub hlwb, qib ntawm ROS hauv HAEC cov hlwb tau nce ntxiv tom qab kev txhawb nqa nrog ox-LDL. Txawm li cas los xij, kev kho mob nrog cov tshuaj sib txawv ntawm AK47 txo qis ntawm cov cellular ROS cov ntsiab lus, qhia tias nws tuaj yeem txo cov cellular oxidative puas.

②Modulate lipid metabolism

Hauv qhov kev sim no, tus qauv kev rog tau tsim nyob rau hauv ApoE gene knockout (ApoE^-/-) nas los ntawm inducing rog rog nrog cov khoom noj uas muaj rog. Cov pab pawg tswj hwm thiab pawg qauv tau muab faib ua glycerin npaj yam tsis muaj AK47, thaum pab pawg AKK cuam tshuam nrog glycerin npaj muaj 1 × 10.⁹cev AK47. Gavage tau ua ib zaug ib hnub ntawm ib koob ntawm 0.1 mL rau 4 lub lis piam. Cov teebmeem ntawm AK47 ntawm cov ntshav lipid metabolism hauv cov ntsuas (TG, TC, HDL-C, LDL-C) tau pom. Cov txiaj ntsig kev sim tau pom nyob rau hauv cov lus hauv qab no. Cov ntshav lipid metabolism ntsuas TG, TC, thiab LDL-C hauv pawg HH-AKK1 cuam tshuam tau qis dua li cov hauv pawg qauv, thiab TG thiab LDL-C tau qis dua cov hauv pawg tswj hwm, qhia tias AK47 tuaj yeem ua tau. thim rov qab cov lipid metabolism txawv txav tshwm sim los ntawm kev noj zaub mov muaj roj ntau.

Table 1. Cov ntsuas ntshav lipid metabolism ntsig txog

Qhov taw qhia (mmol / L)	Tswj pawg	Qauv pawg	AKK kev cuam tshuam pab pawg
TG	1.10±0.11	1.59±0.20	0.82±0.15
TC	3.62±0.67	5.08±0.74	3.05±0.61
HDL-C	715.27±188.46	425.93±131.26	923.55±109.16
LDL-C	4.95±0.51	6.51±0.76	3.15±0.93

③ Kho cov kab mob cytokines

Cov teebmeem ntawm AK47 ntawm inflammatory cytokines (IL-1, IL-6, IL-8, IL-10, C-reactive protein, TNF-, thiab monocyte chemoattractant protein{{ 7}} (MCP-1)) tau pom nyob rau saum cov nas rog rog. Cov txiaj ntsig kev sim tau pom nyob rau hauv cov lus hauv qab no. Cov kab mob inflammatory cytokines IL-1, IL-6, IL-8, CRP, TNF- , thiab MCP-1 hauv pab pawg HH-AKK1 cuam tshuam tau qis dua li cov nyob hauv pab pawg qauv thiab pawg tswj hwm, qhia tias nws tuaj yeem txo cov qib ntawm cov ntshav qab zib hauv cov nas rog rog.

Table 2. Inflamation cytokines nyob rau hauv ntau pawg nas

Cytokines	Tswj pawg	Qauv pawg	AK47 pab
IL-1(pg/ml)	121.88±24.78	189.45±31.27	74.15±25.47
IL-6(pg/ml)	76.63±7.49	103.62±9.53	61.29±10.22
IL-8(pg/ml)	81.08±10.97	105.49±6.75	63.44±10.62
IL-10(pg/ml)	219.52±61.72	244.08±46.22	256.85±52.37
CRP (ng / ml)	127.28±20.54	175.32±24.51	85.33±24.07
TNF (pg / ml)	510.42±45.66	658.17±61.88	370.45±45.70
MCP-1(pg/ml)	19.83±2.16	28.21±2.33	10.19±1.64

Daim ntawv thov

PasteurizedAkkermansia muciniphilaAK47 khov-qhuav hmoov tuaj yeem siv dav hauv cov khoom noj, kev noj haus ntxiv, thiab tshuaj.

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