Probiotics Rau Ntshav Qab Zib

1. Khoom taw qhia
Khoom npe: Probiotic hypoglycemic capsules
Khoom specifications: 30 capsules/box
Cov khoom hnyav: 0.5 g / ntsiav tshuaj
Yuav noj li cas: Raws li kev noj tshuaj metformin, noj cov tshuaj probiotic Jiangdiace capsules, 0.5 g/capsule, 2 capsules ib zaug, ib zaug/d, thiab txuas ntxiv kho cov tshuaj.
Kev ceev faj: Nws yog contraindicated rau cov poj niam cev xeeb tub, cov me nyuam mos, thiab cov me nyuam yaus, cov neeg mob uas muaj cua sov siab heev, thiab cov neeg uas muaj yin deficiency thiab hluav taws kub heev. Nws tsis pom zoo kom noj cov zaub mov ntsim thiab txias thaum noj nws.
Txoj kev khaws cia: Khaws rau hauv qhov chaw txias thiab qhuav, zoo dua tso rau hauv tub yees ntawm 4 degree.
Cov kab mob muaj peev xwm suav tau: Probiotic sib xyaw (40 billion CFU / g), suav nrog Lactobacillus plantarum HH-LP 56 (20 billion CFU / g) thiab Lactobacillus paracasei HH-LP 58 (20 billion CFU / g).
Lwm cov khoom xyaw: Momordica charantin, ntsuab tshuaj yej essence, inulin, thiab fructooligosaccharides.
Nqe lus piav qhia: Pab kev noj qab haus huv ntawm plab hnyuv, muaj cov tshuaj ntsuab hauv Suav teb, thiab txhawb nqa lub cev zais cia ntawm GLP-1.

2. Kev tshawb nrhiav neeg siv khoom
Hauv txoj kev tshawb no, 30 tus neeg laus hnub nyoog ntawm 55 thiab 65 xyoos raug xaiv, thov kom haus cov tshuaj tiv thaiv kab mob probiotic txhua hnub rau 90 hnub, thiab ua tiav daim ntawv nug. Cov neeg mob ntshav qab zib feem ntau qhia cov yam ntxwv xws li "polydipsia, polyphagia, polyuria, poob phaus" thiab tsis muaj zog. Cov lus hauv qab no qhia txog kev txhim kho cov tsos mob tsis zoo ntawm cov neeg mob.

Table 1 Kev txhim kho cov tsos mob tsis zoo ntawm cov neeg mob

3. Probiotics thiab Ntshav Qab Zib
Txoj kev kho Probiotic tam sim no tau txais kev saib xyuas ntxiv raws li lub tswv yim ntxiv rau kev kho tshuaj uas yog tus nqi qis thiab tsis muaj kev phiv.

Table 2 Feem ntau siv kev kho mob ntshav qab zib

4. Cov txheej txheem hypoglycemic ntawm probiotics
Kev tshawb fawb qhia tau hais tias cov txheej txheem ntawm kev ua ntawm probiotics hauv kev tswj cov ntshav qab zib yuav suav nrog cov hauv qab no: (1) tswj cov ntshav qab zib los ntawm kev nce qib adiponectin; (2) tswj cov ntshav qab zib los ntawm inducing lub secretion ntawm glucagon-zoo li peptide-1 (GLP-1); (3) tswj cov ntshav qab zib los ntawm kev txhim kho cov tshuaj insulin; (4) Tswj cov ntshav qab zib los ntawm kev txo qis qhov mob; (5) Tswj cov ntshav qab zib los ntawm kev txhim kho kev tiv thaiv; (6) Tswj cov ntshav qab zib los ntawm kev txhim kho plab hnyuv. Ntawm lawv, inducing GLP-1 secretion yog ib qho tseem ceeb rau probiotics los tswj cov ntshav qab zib. Yog li ntawd, peb yuav txheeb xyuas ntxiv txog cov txheej txheem ntawm GLP-1 tswj cov ntshav qab zib.

5. GLP-1 hypoglycemic mechanism
GLP-1 yog ib qho incretin-hypoglycemic hormone uas tuaj yeem tsim cov tshuaj insulin inhibit qhov rog thiab txo cov ntshav qab zib hom 2. Nyob rau hauv xyoo tas los no, tsom mining thiab tshuaj xyuas cov probiotics uas tuaj yeem zais GLP-1 tau maj mam dhau los ua kev tshawb fawb.
GLP-1 txoj cai hypoglycemic: kho kev ua haujlwm ntawm pancreatic beta hlwb, txhawb nqa pancreatic beta cell faib, thiab txhawb kev tso tawm insulin; prolongs lub sij hawm sib kis ntawm kev tshaib kev nqhis teeb liab los ntawm plab hnyuv hlwb mus rau lub paj hlwb, ncua lub plab khoob, thiab txo cov qab los noj mov; inhibits daim siab qabzib Xenobiotics txhawb nqa cov piam thaj los ntawm lub plawv, txo glucagon secretion, txo qis cov piam thaj reabsorption hauv ob lub raum, thiab txo cov ntshav qab zib ntau ntau.

6. Kev rho tawm thiab tshuaj xyuas cov tshuaj probiotics
Cov kab mob muaj txiaj ntsig tau raug cais tawm thiab tshuaj xyuas los ntawm cov khoom noj fermented xws li kimchi, thiab 16S rDNA gene sequence tau siv los xyuas kom meej tias cov kab mob tau txais muaj kev nyab xeeb thiab txhim khu kev qha thiab yuav tsis ua mob rau tib neeg lub cev. Los ntawm kev sib piv qhov sib txawv ntawm hom kab mob hauv kev txhawb nqa GLP-1 tso zis hauv nas, 4 hom kab mob probiotics uas muaj peev xwm hypoglycemic cuam tshuam tau pib tshuaj xyuas, thiab tom qab ntawd muab piv nrog lawv qhov kam rau ua rau gastric acid thiab bile ntsev thiab mucosal adhesion, thiab rov kuaj dua. kom tau Lactobacillus plantarum HH-LP 56 thiab Lactobacillus paracasei HH-LP 58 yog ob hom probiotic uas tuaj yeem txo cov ntshav qab zib thiab colonize zoo hauv lub cev.

7. Kev txheeb xyuas cov nyhuv hypoglycemic
Ua ntej, tus qauv nas ntshav qab zib tau tsim. Cov nas tsuag tau noj nrog cov rog rog thiab cov qab zib siab noj rau 8 lub lis piam kom lawv cov ntshav qab zib nce ntxiv. Tom qab ntawd streptozotocin txhaj ib zaug los rhuav tshem cov cell uas zais cov tshuaj insulin los tsim cov nas ntshav qab zib hom 2. Qauv. Cov nas sim tau muab faib ua pawg ib txwm, pawg qauv (cov nas mob), pawg tshuaj zoo (cov pab pawg metformin), cov tshuaj tiv thaiv kab mob siab ntau (90 mg / kg / d), thiab cov tshuaj tsis muaj tshuaj sib xyaw probiotic pawg (90 mg / d) kg / d). Cov nas sim tau pom los ntawm kev tswj hwm intragastric rau 4 lub lis piam, thiab GLP tshwm sim los ntawm cov koob tshuaj sib txawv ntawm cov tshuaj probiotics tau muab piv los ntawm kev kuaj ntshav qabzib sai, GLP-1 thiab PYY (peptide tyrosine) cov ntsiab lus hauv cov ntshav, thiab colonic GLP{11. }} qib protein. -1 muaj peev xwm zais cia.
Lus Cim: Cov kab mob cov hmoov uas siv nyob rau hauv high-dose compound probiotic pawg muaj qhov suav tau ntawm 40 billion (2.0×1010 CFU/g HH-LP 56 thiab 2.0 × 1010 CFU/g HH-LP 58). Cov kab mob cov hmoov siv nyob rau hauv cov tshuaj tsawg-dose compound probiotic pawg Cov kab mob muaj peev xwm suav tau yog 4 billion (2.0 × 109 CFU / g HH-LP 56 thiab 2.0 × 109 CFU / g HH-LP 58).
Cov txiaj ntsig kev xeem yog raws li nram no:

Table 3 Cov nyhuv ntawm cov tshuaj probiotics rau kev yoo mov ntshav qabzib (FBG) hauv cov nas (mmol / L)

Piv nrog rau cov nas nyob rau hauv ib txwm pab pawg neeg, FBG nyob rau hauv cov qauv pab pawg neeg yog ho ntau dua li nyob rau hauv cov pab pawg neeg ib txwm los ntawm ua ntej kev cuam tshuam rau 4 lub lim tiam ntawm kev cuam tshuam; piv nrog cov nas hauv pawg qauv, pawg metformin thiab cov tshuaj tiv thaiv kab mob siab heev los ntawm lub lim tiam thib 3 txog rau lub lim tiam thib 4 ntawm kev cuam tshuam Lub FBG ntawm pawg tswj hwm tau txo qis, thiab FBG ntawm cov tshuaj qis qis hauv pawg probiotic yog txo qis hauv 4 lub lis piam.

Table 4 Cov teebmeem ntawm compound probiotics ntawm cov ntshav GLP-1 thiab PYY hauv nas

Piv nrog rau cov pab pawg ib txwm muaj, cov ntshav qab zib GLP-1 thiab PYY cov ntsiab lus ntawm cov nas hauv pawg qauv tau txo qis heev. Piv nrog rau pawg qauv, GLP-1 thiab PYY cov ntsiab lus ntawm nas nyob rau hauv pawg metformin, cov tshuaj tsis tshua muaj tshuaj lom neeg probiotic pawg, thiab cov tshuaj sib xyaw ua ke probiotic ntau ntxiv.

Daim duab 1 Cov nyhuv ntawm cov tshuaj sib xyaw probiotics ntawm nas nyuv GLP-1 qib protein

Piv nrog rau cov pab pawg ib txwm muaj, GLP-1 qib protein nyob rau hauv txoj hnyuv ntawm cov nas hauv pawg qauv tau txo qis-tswj; piv nrog rau pawg qauv, GLP-1 qib protein ntawm nas nyob rau hauv pawg metformin, qis-dose compound probiotic pawg, thiab high-dose compound probiotic pawg tau nce ntau.
Tom qab tswj hwm 4. {5}} protein nyob rau hauv txoj hnyuv tau ntsuas. Qib, cov txiaj ntsig tau pom tias cov kab mob probiotic Lactobacillus plantarum HH-LP 56 thiab Lactobacillus paracasei HH-LP 58 tau pom tias muaj peev xwm ua rau GLP-1 tso tawm, qhia lawv lub peev xwm los txo cov ntshav qab zib hauv cov neeg mob ntshav qab zib.

cov ntaub ntawv:
[1] Sun Xin, Galhasbek Selik, Wang Yanming, thiab lwm yam. Cov txiaj ntsig thiab kev tswj hwm cov txheej txheem ntawm cov mis-derived compound probiotics ntawm GLP-1 hauv hom 2 mob ntshav qab zib nas [J]. Suav Journal of Microecology, 2020, 32(04): 384-391. DOI: 10.13381/j.cnki.cjm.202004003
[2] L Tian, ​​R Zhao, X Xu, Zhou, X Xu, D Luo, Zhou, Y Liu, A Kushmaro, R. S. Marks, A Dinnyés, Q Sun, 2023. Modulatory teebmeem ntawm Lactiplantibacillus plantarum rau mob kab mob metabolic. Food Science thiab Human Wellness, 12 (4): 959-974. https://doi.org/10.1016/j.fshw.2022.10.018.
[3] Y Wang, D Dilidaxi, Y Wu, J Sailike, X Sun, X Nabi, 2020. Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db nas. Biomed Pharmacother, Tsib Hlis: 125:109914. doi 10.1016/j.biopha.2020.109914.

8. Tib neeg koob tshuaj hloov dua siab tshiab
Qhov pom zoo noj probiotic txhua hnub ib kilogram rau nas yog 90 mg × 4.0 × 1010CFU / g, uas yog 3.6 × 109CFU;
Hloov raws li lub cev hnyav ntawm 70 kg, qhov sib npaug ntawm cov nas yog sib npaug rau 6.3 npaug ntawm tib neeg lub cev. Qhov pom zoo noj probiotic txhua hnub rau tus neeg laus qhov hnyav 70 kg yog 3.6 × 109CFU÷ 6.3 × 70 kg, uas yog, 4.0 × 1010CFU.

9. Kev soj ntsuam ntawm excipients
Momordica charantin (peptides, polysaccharides, steroidal saponins): kho pancreatic beta hlwb puas, txhim kho cov qib insulin thiab rhiab heev; inhibits kev nqus ntawm cov piam thaj los ntawm inhibiting glucosidase, thiab inhibits kev ua ntawm disaccharides kom ua rau cov nyhuv hypoglycemic.
Ntsuab tshuaj yej essence: tshuaj yej polyphenols, tshuaj yej polysaccharides, tshuaj yej pigments, vitamins, thiab tej yam minerals nyob rau hauv tshuaj yej muaj ib tug tej yam inhibitory nyhuv ntawm cov ntshav qab zib. Cov tshuaj yej polyphenols hauv cov tshuaj yej ntsuab muaj lub luag haujlwm ntawm kev tiv thaiv pancreatic beta hlwb, antioxidants, thiab scavenging. Kev ua haujlwm ntawm cov dawb radicals.
Inulin thiab fructooligosaccharides: feem ntau siv prebiotics los txhawb kev loj hlob thiab metabolism ntawm probiotics hauv lub cev.

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