Probiotics Rau Mob raum Kab Mob

Specifications: 0.5g × 60 capsules/box

Formula (cov ntsiab lus ntawm ib ntsiav tshuaj):
Lactobacillus plantarum N-1: 25 Billion CFU
Lactobacillus johnsonii LBJ456: 25 Billion CFU
Bifidobacterium animalis HH-BAA68: 25 Billion CFU
Lactobacillus casei PB-LC39: 15 Billion CFU
Lactobacillus acidophilus HH-LA26: 10 Billion CFU
Fucoidan 80mg, Poria cocos hmoov 60mg, Konjac hmoov 60mg, galactooligosaccharide 50mg

Cov mis probiotic no yog kho kom txo tau cov kab mob raum ntev. Cov mis probiotic no muaj patented thiab scientifically proven probiotic hom Lactobacillus plantarum N-1, uas yog scientific proven rau:
√ Kho nephritis
√ Tiv thaiv lub raum pob zeb
Cov koob tshuaj pom zoo: rau theem kab mob raum 1-2, noj ib hnub ib zaug, tom qab noj mov, 3-4 tshuaj ntsiav ib hnub, tsawg kawg yog ob lub hlis. Rau theem 3-4 kab mob raum, noj 2 zaug hauv ib hnub, tom qab noj mov, 3-4 ntsiav tshuaj ib hnub, tsawg kawg yog 4 lub hlis. Rau theem 5 mob raum, noj 3 zaug hauv ib hnub, tom qab noj mov, 3-4 ntsiav tshuaj ib hnub, tsawg kawg yog 6 lub hlis.
Txoj kev cia: Khaws kom deb ntawm lub teeb thiab ntawm qhov kub thiab txias, nyiam dua 4 degree.

Txhua theem ntawm mob raum mob

Cov kab mob raum tsis zoo (CKD) muaj tsib theem, uas yog nyob ntawm seb koj lub raum ua haujlwm zoo npaum li cas1234.

Cov theem yog raws li nram no: Theem 1: Lub raum mob me me, eGFR 90 lossis siab dua.

Theem 2: Lub raum tsis ua haujlwm me me, eGFR 60-89.

Theem 3a & 3b: Me me mus rau lub raum tsis ua haujlwm hnyav, eGFR 30-59.

Kauj Ruam 4: Lub raum tsis ua haujlwm hnyav, eGFR 15-29.

Theem 5: Lub raum tsis ua haujlwm lossis ze rau qhov tsis ua haujlwm, eGFR tsawg dua 15.

Kev sib raug zoo ntawm plab hnyuv flora thiab mob raum kab mob

Muaj ob txoj kev sib raug zoo ntawm dysbiosis thiab pathogenesis ntawm CKD. Peb xaus qhov kev sib raug zoo no hauv daim duab 1.:

DAIM 1 |Kev sib raug zoo ntawm plab microbiome thiab mob raum kab mob (CKD) yog ob txoj kev. Hauv ib qho kev taw qhia, lub plab microbiota cuam tshuam rau lub raum; qhov tshwm sim lub luag haujlwm ntawm plab microbiota hauv(A) Lub cev noj qab nyob zoo,(B) Lub plab zom mov vim microbial dysbiosis thiab cuam tshuam ntawm txheej mucosal,(C) Kev tso tawm ntawm pro-inflammatory yam nyob rau hauv cov hlab ntsha thiab pib ntawm inflammatory cascade, tsub zuj zuj ntawm uremic toxins,(D) Kev poob qis hauv kwv yees glomerular filtration rate (eGFR), qhov nce ntawm albumin creatinine piv (ACR) thiab poob ntawm cov haujlwm endocrine ntawm lub raum. Nyob rau hauv lwm yam lus, CKD tsav dysbiosis nyob rau hauv lub plab (qhia los ntawm dotted xub) thiab pib ib tug inflammatory cascade.

Lub pathogenesis ntawm mob raum kab mob raws li txoj hnyuv microecology
1. Kev tsim cov urinary co toxins thiab inflammatory teb mechanism lawv induce
Nyob rau hauv ib txwm muaj physiological tej yam kev mob, cov kab mob uas muaj txiaj ntsig thiab cov kab mob tsis zoo ua rau muaj kev sib npaug sib npaug. Raws li CKD vam meej, cov kab mob pathogenic loj hlob thiab rov tsim dua tshiab, rhuav tshem qhov sib npaug ntawm cov kab mob muaj txiaj ntsig thiab cov kab mob tsis zoo, thiab ua rau muaj kev hloov pauv hauv plab hnyuv ib puag ncig. Raws li qhov chaw no, urea compensatoryly nkag mus rau hauv txoj hnyuv lumen. Nyob rau hauv qhov kev txiav txim ntawm urease-expressing cov kab mob, urea yog hydrolyzed, tso ib tug loj npaum li cas ntawm ammonia, thiab plab hnyuv pH nqi nce, uas yog conducive rau kev loj hlob ntawm pathogenic kab mob [1] thiab aggravates plab hnyuv kab mob. , txhawb kev tsim cov urinary toxins [2]. Tam sim no, ntau tshaj 90 hom uremic toxins tau raug tshaj tawm. Txawm hais tias qee qhov uremic toxins tuaj yeem tawm hauv cov quav, qee qhov tau nqus thiab khaws cia hauv lub cev ntawm cov neeg mob CKD, ua rau thiab txhawb kev puas tsuaj rau lub raum qauv thiab ua haujlwm nyob rau theem pib ntawm cov kab mob raum.
2. Kev puas tsuaj ntawm cov kab mob hauv plab hnyuv thiab translocation ntawm cov kab mob metabolites
Los ntawm metabolizing zaub mov, lub plab hnyuv muaj peev xwm koom nrog lub zog mov ntawm plab hnyuv epithelial hlwb los ntawm kev tsim luv-chain fatty acids (SC-FAs); tswj cov pH ntawm txoj hnyuv lumen, txhim kho cov acidic ib puag ncig, txo kev loj hlob ntawm cov kab mob phem; thiab inhibiting pro-inflammation Factor ntau lawm, txo inflammatory teb [3]. Cov kab mob hauv plab hnyuv ntawm cov neeg mob CKD yog qhov tsis zoo, uas yog, cov kab mob pathogenic ua rau muaj kev cuam tshuam rau lub cev ua haujlwm ntawm txoj hnyuv. Cov kab mob plab hnyuv raug puas lawm thiab cov plab hnyuv tawm tshwm sim [1], thiab cov kab mob metabolites yog translocated, yog li ua rau lub cev o.

Cov txiaj ntsig zoo ntawm probiotics hauv kev txhim kho nephritis ntev yog feem ntau tshwm sim hauv:
Ua ntej ntawm tag nrho cov, probiotic supplementation tuaj yeem txhim kho qib ntawm o thiab oxidation hauv lub cev: los ntawm kev tswj cov ntshav lipopolysaccharide qib, txo cov qog necrosis factor (TNF-), interleukin 6 thiab C-reactive protein (C-reactive protein (CRP)) qib; Nyob rau tib lub sijhawm, nws nce qib superoxide dismutase thiab tag nrho cov antioxidant muaj peev xwm, yog li ncua kev loj hlob ntawm lub raum kab mob.
Tsis tas li ntawd, kev ntxiv cov probiotics tuaj yeem txo cov ntshav neurotoxin qib, suav nrog indoxyl sulfate (IS) p-cresyl sulfate (PCS), thiab lwm yam uremic toxin molecules uas nyuaj rau tshem tawm los ntawm hemodialysis [4]. Nws kuj yog nrog los ntawm kev txo qis hauv cov ntshav urea nitrogen theem, uas pab ncua kev loj hlob ntawm cov kab mob raum. Probiotic supplementation tuaj yeem kho cov metabolism hauv plab hnyuv thiab txo cov qib tsim cov tshuaj urinary. Probiotics kuj tseem tuaj yeem pab txo cov kab mob hauv nruab nrog cev, suav nrog txo cov kab mob glomerular thiab tubulointerstitial; tswj kev ncaj ncees ntawm cov kab mob hauv plab hnyuv, ntxiv dag zog rau cov kev sib tshuam nruj ntawm cov hnyuv epithelial hlwb, thiab tswj kev ncaj ncees ntawm txoj hnyuv villus qauv [5].
Thaum mob raum mob mus rau theem kawg ntawm lub raum kab mob, cov neeg mob feem ntau yuav tsum tau hloov lub raum los yog lub raum mus sij hawm ntev dialysis kom muaj sia nyob. Kev noj cov tshuaj probiotic ntxiv tuaj yeem muaj ntau yam txiaj ntsig zoo rau kev noj qab haus huv ntawm cov neeg mob lub raum dialysis. Qee cov kev tshawb fawb pej xeem tau pom tias kev noj cov tshuaj probiotic tuaj yeem txhim kho qhov tshwm sim thiab qhov tshwm sim ntawm ntuav, kub hnyiab, thiab mob plab hauv cov neeg mob hemodialysis [6].

Lactobacillus plantarum N-1
Qhov chaw ntawm cov kab mob: Yak cheese los ntawm Qinghai-Tibet Plateau
Tus lej sau: CGMCC No.15463
Acid thiab kua tsib ntsev tsis kam
Acid thiab bile kam rau ua yog cov khoom tseem ceeb tshaj plaws ntawm probiotics vim tias lawv txiav txim siab lawv lub peev xwm kom muaj sia nyob hauv cov hnyuv me thiab yog li siv lawv lub luag haujlwm ua probiotics. N-1 pom tau tias muaj sia nyob zoo heev ntawm pH qis thiab siab siab ntsev ntsev concentration.

adhesion
Kev muaj peev xwm ua raws li tus tswv tsev yog qhov tseem ceeb rau kev tshuaj xyuas cov muaj peev xwm probiotics. Nws tau xav tias yuav cuam tshuam nrog kev colonization, kev tiv thaiv kab mob, kev tiv thaiv kev tiv thaiv kab mob, thiab kev txhim kho ntawm kev ua haujlwm tsis zoo. Cov txiaj ntsig ntawm adhesion test tau pom tias cov adhesion naj npawb ntawm N-1 rau Caco-2 hlwb yog 6.04 × 106 CFU/mL, thiab tus nqi adhesion yog 4.03%.
Lus Cim: Tus qauv Caco-2 cell yog ib tug tib neeg cloned colon adenocarcinoma cell. Nws cov qauv thiab kev ua haujlwm zoo ib yam li qhov sib txawv ntawm cov hnyuv me me epithelial hlwb. Nws muaj cov qauv xws li microvilli thiab muaj cov enzyme systems uas cuam tshuam nrog txhuam ciam teb epithelium ntawm txoj hnyuv me. Nws tuaj yeem siv los ua kev sim simulating plab hnyuv thauj hauv vivo.
Probiotics kho cov kab mob hauv lub raum puas hauv cov kab mob raum
Lub luag haujlwm tseem ceeb ntawm txoj hnyuv mucosa yog nqus cov as-ham, zais cov khoom pov tseg, thiab ua haujlwm los tiv thaiv kev nqus pov tseg thiab tiv thaiv cov kab mob thiab lawv cov khoom tsis zoo hauv cov hnyuv lumen los ntawm kev nkag mus rau tib neeg lub cev ib puag ncig [7-8 ].

Raws li H & E staining cov txiaj ntsig ntawm nas nyuv hauv daim duab 2, piv nrog rau pawg neeg ua haujlwm sham, crypt qhov tob thiab mucosal thickness ntawm cov nyuv cov ntaub so ntswg nyob rau hauv cov qauv pab pawg neeg tau txo qis (P<0.05); and compared with the model group, the probiotics The crypt depth and mucosal thickness of the group were significantly increased (P<0.05), indicating that the morphology of the colonic mucosa was restored to a certain extent after probiotic administration. The concentration of dopamine in the brains of mice in the daily probiotic group reached a statistical difference, which increased by 27% compared with the disease-causing group, and the effect was significant.
Cov teebmeem ntawm probiotics ntawm txoj hnyuv epithelial nruj hlws ris proteins nyob rau hauv nas nrog mob raum kab mob
Raws li daim duab 4, tom qab kev tswj hwm qhov ncauj ntawm cov tshuaj probiotics, qib ntawm ZO-1 thiab Claudin{2}} cov proteins hauv cov nyuv ntawm nas tau nce ntau (P<0.05), indicating that probiotics can repair the damaged intestinal tight junctions to a certain extent. , reduce harmful substances and antigens in the intestines from entering the body, and inhibit the body's immune response.

2.4 Cov txiaj ntsig ntawm kev sib xyaw probiotics ntawm cov ntshav cytokines hauv cov nas uas muaj kab mob raum
Cov kev sim tau pom tias piv nrog rau pawg neeg ua haujlwm sham, C-reactive protein cov ntsiab lus hauv cov ntshav ntawm cov nas hauv pawg qauv tau nce ntxiv, qhia tias cov nas hauv pawg qauv tau ntsib kev mob. Qhov tshwm sim no tuaj yeem tshwm sim los ntawm kev puas tsuaj rau lub plab zom mov thiab tom qab kev tswj hwm intragastric ntawm probiotics tshwm sim los ntawm lipopolysaccharide nkag mus rau hauv lub cev, C-reactive protein cov ntsiab lus nyob rau hauv cov ntshav ntawm cov nas hauv pawg probiotic tau txo qis dua piv nrog cov nas hauv lub cev. pawg qauv, qhia tias cov khoom no probiotic tuaj yeem cuam tshuam cov lus teb inflammatory hauv cov nas uas muaj kab mob raum. Ua ke nrog cov txiaj ntsig kev sim yav dhau los, kev cuam tshuam probiotic tuaj yeem kho cov kab mob plab hnyuv puas tsuaj los ntawm lub raum tsis txaus. Probiotics tuaj yeem txo cov kab mob hauv plab hnyuv thiab lwm yam khoom txawv teb chaws nkag mus rau hauv lub cev los ntawm kev txhim kho cov kab mob plab hnyuv, yog li txo qhov mob ntawm cov nas uas muaj kab mob raum. Phem. Tsis tas li ntawd, piv nrog pab pawg neeg ua haujlwm sham, cov theem ntawm cov teeb meem pro-inflammatory TNF- (P<0.05) and IL-6 (P>0.05) nyob rau hauv cov ntshav cov nas nyob rau hauv cov qauv pab pawg neeg tau nce, thiab cov theem ntawm anti-inflammatory yam tseem ceeb IL-10 (P<0.05) were increased. and IL-13 (P<0.05) significantly decreased, indicating that the innate immune system in rats with chronic kidney disease was stimulated, which was consistent with the results of C-reactive protein. Compared with the probiotic group, the levels of pro-inflammatory factors TNF-α (P<0.05) and IL-6 (P>0.05) nyob rau hauv cov ntshav ntawm nas nyob rau hauv pawg probiotic txo. Cov theem ntawm cov tshuaj tiv thaiv kab mob IL-10 (P<0.05) and IL-13 (P< 0.05) content increased significantly, indicating that probiotics improve the immune imbalance and inflammatory response in rats by regulating the levels of pro-inflammatory factors and anti-inflammatory factors in the serum.

Raw khoom los ntawm tib lub hauv paus chiv keeb li tshuaj thiab zaub mov:
fucodan
Fucoidan, hu ua fucoidan los yog fucoidan, yog marine complex polysaccharide tsim los ntawm fucose-muaj sulfate pawg. Fucoidan tuaj yeem txhim kho lub plab zom mov, ua kom muaj zog polysaccharide, thiab muaj cov txiaj ntsig zoo ntawm kev kho mob raum tsis ua haujlwm thiab txhim kho kev tiv thaiv.
Konjac hmoov
Glucomannan muaj nyob rau hauv konjac muaj zog o lub zog thiab yog nkig thiab tawv dua txhua yam ntawm cov pos hniav. Nws tuaj yeem sau cov hnyuv thiab plab, detoxify thiab txo qhov o, thiab nthuav cov hnyuv kom txo tau cem quav. Kev noj zaub mov fiber ntau hauv konjac tuaj yeem txhawb kev zom zaub mov thiab ua kom lub plab zom mov. Lub tsub zuj zuj ntawm cov rog nyob rau hauv cov hnyuv tso cai rau cov tshuaj lom kom tawm ntawm lub cev, soothes cov hnyuv, detoxifies, thiab ntxuav lub plab.
Poria hmoov
Poria cocos hmoov yog cov hmoov ntawm cov tshuaj suav tshuaj Poria cocos. Nws feem ntau yog dawb los yog lub teeb grey thiab tig tsaus grey tom qab brewing. Nws yog qhov me me, qab zib, thiab lub teeb hauv saj, thiab muaj triterpenes, polysaccharides, choline, rog, lecithin, potassium, magnesium, thiab lwm yam. Nws muaj cov teebmeem ntawm diuresis thiab dampness, ntxiv dag zog rau tus po thiab calming lub plawv. Poria cocos tuaj yeem tsis tsuas yog txhim kho lub cev tiv thaiv kab mob, tab sis kuj ua rau oxyhemoglobin hauv cov ntshav tso tawm ntau dua oxygen los muab cov ntaub so ntswg.

Cov ntawv & Patents

1. JAZANI NH, SAVOJ J, LUSGARTEN M, et al. Kev cuam tshuam ntawm plab dysbiosis ntawm cov kab mob neurohormonal hauv cov kab mob raum ntev [J]. Kab mob, 2019,7(1): 21.

2. YANG T, RICHARDS EM, PEPINE CJ, et al. Lub plab microbiota thiab lub hlwb-lub plab-mob axis hauv ntshav siab thiab mob raum mob [J]. Nat Rev Nephrol, 2018, 14(7): 442-456.

3. 刘松珍, 张雁, 张名位, 等. 肠道短链脂肪酸产生机制及生理功能的研究进展[ J]. 广东农业科学, 2013, 40 ( 11): 99 -103.

4. LOPES R, THEODORO JMV, DA SILVA BP, et al. Synbiotic pluas noj txo qis uremic toxins hauv cov neeg mob hemodialysis: kev sim tshuaj placebo-tswj [J]. Food Research International, 2019, 116: 241-248.

5. LIOR L, CAO YG, KATHRIN F, et al. Kev noj haus posttranslationally hloov cov nas plab microbial proteome los hloov lub raum ua haujlwm [J]. Science, 2020, 369: 1518-1524.

6. VIRAMONTES-HORNER D, MARQUEZ-SANDOVAL F, MARTINDEL-CAMPO F, thiab al. Cov nyhuv ntawm symbiotic gel (Lactobacillus acidophilus + Bifidobacterium lactis + inulin) ntawm qhov muaj thiab mob hnyav ntawm plab hnyuv hauv cov neeg mob hemodialysis [J]. Phau ntawv Journal of Renal Nutrition, 2015, 25(3): 284-291.

7. CAMILLER M, MADSEN K, SPILLER R. Cov kab mob plab hnyuv ua haujlwm hauv kev noj qab haus huv thiab kab mob plab[J].Neurogastroenterology and Motility,2012, 24(6):503-512.

8. MATTHEW AO, JERROLD R T. Lub plab hnyuv epithelial barrier: lub hom phiaj kho[J].Nature Reviews Gastroenterology & Hepatology,2017,14(1):9-12.

9. LEE BT, AHMED FA, HAMM LL, et al. Association ntawm C-reactive protein, qog necrosis factor-alpha, thiab interleukin -6 nrog rau mob raum[J]. BMC Nephrology, 2015, 16(1): 1-6.

10. YEUN JY, Levin RA, MANTA V, et al. C-reactive protein kwv yees txhua qhov ua rau thiab mob plawv tuag hauv cov neeg mob hemodialysis [J]. American Journal of Kidney Diseases,2000,35(3):469-476.

11. MACHOWAKA A, CARRERO JJ, LINDHOLM B, et al. Cov kws kho mob tsom rau qhov mob tsis tu ncua hauv cov kab mob raum mob ntev [J]. Kev Tshawb Fawb Kev Txhais Lus, 2016, 167(1): 204-213.

12. STENVINKEL P, KETTELER M, JOHNSON RJ, et al.IL-10, IL-6 thiab TNF-alpha: Lub hauv paus tseem ceeb hauv kev hloov pauv cytokine network ntawm uremia-qhov zoo, qhov tsis zoo, thiab cov loj [J]. Raum International, 2005,67(4): 1216-1233.

13. GIRNDT M, GUZMAN NJ, BALAKRISHNAN VS, et al. Kev koom tes ntawm albuminuria, lub raum ua haujlwm, thiab inflammatory biomarker profile hauv CKD hauv CRIC [J]. Clinical Journal of the American Society of Nephrology,2012,7(12):1938-1946.

14. WANG IK, WU YY, Yang YF, et al. Cov txiaj ntsig ntawm probiotics ntawm cov ntshav ntawm cytokine thiab endotoxin hauv peritoneal dialysis Cov neeg mob: ib qho randomized, ob-dig muag, placebo-tswj sim [J]. Beneficial Microbes, 2015, 6(4):423-430.

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