1. Khoom taw qhia
- Khoom npe: Allergy rhinitis probiotics ntsiav tshuaj
- Cov khoom specifications: 30pcs / box
- Cov khoom hnyav: 0.5 g / thooj
- Indications: Cov tshuaj muaj pes tsawg leeg muab los ntawm cov khoom no tuaj yeem txo cov tsos mob xws li khaus qhov ntswg, txham, qhov ntswg, thiab lwm yam., thiab muaj txiaj ntsig zoo rau kev ua xua rhinitis.
- Cov lus qhia rau kev siv: 1-2 ntsiav tshuaj txhua hnub. Yaug thiab yaj hauv qhov ncauj. Tsis txhob zom los yog nqos nrog dej. Sim tsis txhob haus dej lossis noj zaub mov tsis pub dhau 2 teev tom qab siv. Lub sijhawm zoo tshaj plaws los siv nws yog ua ntej mus pw hmo ntuj thiab tom qab txhuam koj cov hniav.
- Lus Cim: Nws raug pom zoo tias yuav siv lub voj voog 3- hli, nrog 2 ntsiav tshuaj ib hnub hauv thawj lub hlis thiab 1 ntsiav tshuaj ib hnub hauv ob lub hlis tom ntej kom muab lub sijhawm txaus los ua kom muaj zog thiab ua kom lub ntsws zoo. thaj chaw ib puag ncig.
- Txoj kev khaws cia: Khaws rau hauv qhov chaw txias thiab qhuav, zoo dua tso rau hauv tub yees ntawm 4 degree.
- Cov kab mob uas muaj peev xwm suav tau: kev sib xyaw probiotic (40 billion CFU/g), Bifidobacterium longum HH-BL18 (10 billion CFU/g), Bifidobacterium lactis HH-BA68 (10 billion CFU/g), Lactobacillus rhamnosus PB-LR76 (10 billion CFU/ g) thiab Lactobacillus reuteri PB-LR09 (10 billion CFU/g).
- Lwm cov khoom xyaw: honeysuckle, zib ntab, peppermint roj, kua sucrose, thiab kua qabzib.
2. Technical keeb kwm
Allergic rhinitis (hypersensitive rhinitis), tseem hu ua allergic rhinitis (AR), yog tshwm sim los ntawm kev tiv thaiv kab mob tsis zoo, feem ntau tshwm sim los ntawm lub cev tiv thaiv kab mob rau ntau yam ua xua hloov mus rau Th2 hom, uas yog, Th1 hom hlwb (CD{{2}). }cov hlwb zoo) cov lus teb yog inhibited thiab Th2- hom cell teb yog txhim kho. IFN- (-interferon) thiab IL-12 (interleukin-12) secreted los ntawm Th1 hlwb txo, IL-3, IL-4, thiab IL-5 secreted los ntawm Th2 hlwb nce, stimulating B hlwb los tsim ntau IgE, eosinophils qhib, proliferate thiab tso tawm ntau yam pro-inflammatory mediators, ua rau cov tsos mob xws li txham, qhov ntswg khaus, hypernasal secretion, thiab qhov ntswg qhov ntswg.
Tam sim no, loratadine feem ntau yog siv los kho cov kab mob rhinitis los txo cov tsos mob xws li txham, qhov ntswg, qhov ntswg qhov ntswg, qhov ntswg congestion, qhov muag khaus, thiab kub hnyiab. Txawm li cas los xij, nws cov txiaj ntsig kho thiab kho tus nqi tsis tseem ceeb. Cov kev tshawb fawb pom tau hais tias ntxiv cov nroj tsuag ib txwm muaj ntawm cov kab mob ua pa kom tsim nyog tuaj yeem tswj hwm qhov sib npaug ntawm cov pa microecology, ua rau nws cov nyhuv antagonistic rau cov kab mob txawv teb chaws, thiab inhibit lawv txoj kev loj hlob. Nyob rau tib lub sijhawm, nws tseem tuaj yeem muab cov cim qhia uas txhawb nqa lub cev tiv thaiv kab mob kom loj hlob thiab cov ntaub so ntswg endothelial sib txawv, txhim kho lub cev tiv thaiv kab mob ua haujlwm.
3. Mechanism ntawm probiotics txhim kho cov kab mob ua pa
Cov kev tshawb fawb pom tau hais tias probiotics nyob rau hauv lub ntsws sab sauv tuaj yeem ua tiav kev tiv thaiv kab mob thiab txhim kho kev tiv thaiv los ntawm ntau txoj hauv kev tiv thaiv kab mob, thiab tuaj yeem cuam tshuam kev tsim cov inflammatory cytokines hauv cov hnyuv. Probiotics tsim peb kab hauv qab no tiv thaiv tib neeg lub cev los tiv thaiv thiab kho cov kab mob ua pa: (1) Probiotics ua rau ntawm daim tawv nqaij thiab ua pa mucosa, yog li txhim kho cov tshuaj tiv thaiv tshwj xeeb IgG thiab IgA cov tshuaj tiv thaiv; (2) Txhim kho lub peev xwm ntawm phagocytosis ntawm cov hlwb nyob rau hauv ib txwm muaj xwm txheej thiab qhib Cov tshuaj tua kab mob dissolves phagocytes thiab tshem tawm cov kab mob; (3) Ua kom cov concentration ntawm IFN- (gamma interferon) thiab IL-10 (interleukin-10) nyob rau hauv alveoli thiab txhim khu kev ua haujlwm ntawm NK hlwb (natural killer cells), Txhim kho kev tiv thaiv tus kheej.
4. Hehe Kev Tiv Thaiv Kab Mob thiab Kev Kho Mob ntawm Allergic Rhinitis Strains
Tau qhov twg los thiab kev txheeb xyuas tus kab mob: cais tawm ntawm cov neeg laus txoj hnyuv, 16S rDNA gene sequence tau txiav txim siab kom tau txais cov ntaub ntawv hom nrog cov kab ke zoo sib xws. Kev sib piv homology tau siv los pab txiav txim cov ntaub ntawv hom. Nws tau muab cais tawm thiab npe hu ua Bifidobacterium longum HH-BL18, Bifidobacterium lactis Fibrobacterium HH-BA68, Lactobacillus rhamnosus PB-LR76, thiab Lactobacillus reuteri PB-LR09.
5. Hauv vivo pov thawj
Txoj kev sim: BALB/c nas uas muaj hnub nyoog 6 txog 8 lub lis piam tau muab faib ua pawg tswj hwm, pab pawg probiotic, thiab AR pawg, nrog 10 nas nyob hauv txhua pab. Txoj kev Luminex tau siv los txheeb xyuas cov ntshav IL-4 thiab IFN- qib hauv txhua pab pawg, thiab qib OVA-specific IgE (OVA-SIgE) cov ntshav tau ntsuas los ntawm ELISA.
Cov txiaj ntsig kev xeem: Piv nrog rau pawg AR, tsis muaj qhov sib txawv tseem ceeb hauv cov ntshav IFN- qib ntawm cov nas hauv pawg probiotic, tab sis nws tuaj yeem txo cov ntshav IL-4 thiab OVA-SIgE ntau ntau. Cov txiaj ntsig kev xeem tshwj xeeb yog raws li hauv qab no:
Daim duab 1 OVA-sIgE cov ntsiab lus (ng / mL) hauv cov ntshav nas tom qab 8 lub lis piam ntawm kev tswj hwm
AR yog ib hom kab mob ua xua ntawm lub qhov ntswg mucosa kho los ntawm IgE tom qab cov tib neeg uas muaj kev fab tshuaj tiv thaiv kab mob. Ntshav qab zib IgE qib ntawm cov tib neeg ib txwm muaj tsawg heev, thaum cov ntshav IgE qib ntawm AR cov neeg mob siab. Hauv txoj kev tshawb no, qib ntawm OVA-sIgE hauv cov ntshav ntawm cov nas hauv pawg probiotic tau qis dua li hauv pawg AR, qhia tias kev cuam tshuam ntawm probiotic tuaj yeem txo qhov tsim ntawm OVA-sIgE thiab txo cov kev tsis haum rau hom I.
Daim duab 2 Interleukin-4 (IL-4) cov ntsiab lus (ng/mL) hauv cov ntshav nas tom qab 8 lub lis piam ntawm kev tswj hwm
Daim duab 3 IFN- cov ntsiab lus hauv cov ntshav nas tom qab 8 lub lis piam ntawm kev tswj hwm (pg / mL)
Helper T lymphocyte subpopulations tuaj yeem muab faib ua ob pawg: Th1 thiab Th2 raws li hom cytokines lawv tsim thiab lawv cov haujlwm lom neeg. Th1 hlwb feem ntau zais Th1 cytokines xws li IL-2, IL-12, IFN-, thiab lwm yam, ntawm cov uas, IFN- koom nrog hauv kev tiv thaiv kab mob ntawm tes, thiab Th2 hlwb feem ntau zais ob hom cytokines xws li IL. -4 thiab IL-5. Ntawm lawv, IL-4 feem ntau koom nrog kev tiv thaiv kev lom zem thiab ua rau muaj kev fab tshuaj rau hom I. Cov neeg mob AR muaj qhov tsis txaus ntawm Th1/Th2 hom kev tiv thaiv. Cov lus teb Th2 muaj zog heev thiab Th1 lus teb raug txwv. Probiotic stimulation tuaj yeem tswj tau qhov sib npaug ntawm Th1 / Th2. Cov txiaj ntsig ntawm txoj kev tshawb fawb no tau pom tias Th2 tus neeg sawv cev qhov tseem ceeb IL-4 hauv pawg probiotic tau qis dua li hauv pawg AR, thaum Th1 tus neeg sawv cev qhov tseem ceeb IFN- tsis txawv ntawm AR pawg, qhia tias probiotics Tej zaum yuav ua tiav Th1 los ntawm inhibiting Th2- hom lus teb. / Th2 balanced tsis txhawb Th1 lub cev tiv thaiv kab mob.
Hauv cov ntsiab lus, probiotics tuaj yeem txo qhov tsim ntawm OVA-sIgE thiab inhibit Th2 cov lus teb ntawm tes, yog li tiv thaiv thiab kho cov kab mob rhinitis.
cov ntaub ntawv:
[1] Txiv neej WH, de Steenhuijsen Peters WA, Bogaert D. Cov microbiota ntawm txoj hlab pa: tus neeg saib xyuas kev noj qab haus huv. Nat Rev Microbiol. 2017 May; 15(5):259-270. doi: 10.1038/nrwm.2017.14. Epub 2017 Mar 20. PMID: 28316330; PIB: PMC7097736.
[2] Shah T, Shah Z, Baloch Z, Cui X. Lub luag haujlwm ntawm microbiota hauv kev ua pa thiab kab mob, tshwj xeeb tshaj yog nyob rau hauv tuberculosis. Biomed Pharmacother. Nov 2021; 143:112108 : kuv. doi 10.1016/j.biopha.2021.112108. Epub 2021 Sep 21. PMID: 34560539.
[3] Cao W, Sun Y, Zhao N, Song J, Zhang N, Liu L, Liu Q. Cov yam ntxwv ntawm cov kab mob microbiota nyob rau sab sauv ntawm cov menyuam yaus. Euro Arch Otorhinolaryngol. 2022 Feb; 279(2):1081-1089. doi: 10.1007/s00405-021-07013-y. Epub 2021 Jul 24. PMID: 34304297.
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