Anti Inflamation Probiotics

1. Khoom taw qhia

• Khoom npe: Anti-inflammatory probiotics
• Khoom specifications: 30 capsules/box
• Cov khoom hnyav: 0.5 g / ntsiav tshuaj
• Cov lus qhia rau kev noj: 0.5 g / ntsiav tshuaj, 2 ntsiav tshuaj ib zaug, ib zaug / d, noj tshuaj txuas ntxiv.
• Txoj kev khaws cia: Khaws rau hauv qhov chaw txias thiab qhuav, zoo dua tso rau hauv tub yees ntawm 4 degree.
• Cov kab mob muaj peev xwm suav tau: Thaum tawm hauv lub Hoobkas, cov kab mob uas muaj peev xwm suav tau ntau dua lossis sib npaug li 400 billion CFU / lub thawv, muaj Lactobacillus johnsonii LBJ 456 (200 billion CFU / lub thawv).
• Lwm cov khoom xyaw: mulberries, taum taum, almonds, inulin, thiab fructooligosaccharides.

2. Probiotics thiab mob caj dab

Cov kev tshawb fawb tau pom tias cov kab mob plab hnyuv microbial tuaj yeem ua rau muaj qhov permeability ntawm cov kab mob hauv plab hnyuv mucosa, ua rau cov kab mob hauv plab hnyuv thiab cov metabolites nkag mus rau sab nraud ntawm txoj hnyuv, thiab ua rau lub zos colonization hauv cov kab noj hniav sib koom nrog cov ntshav ncig nyob rau hauv induction ntawm chemokines thiab adhesion molecules, inducing synovial o. tshuaj tiv thaiv. Kev nplua nuj thiab ntau haiv neeg ntawm lub plab microbiota txo qis thaum mob caj dab nce, thiab plab hnyuv tuaj yeem ua rau cov lus teb inflammatory ntxiv. Ntxiv cov probiotics tuaj yeem tsis tsuas yog txhim kho cov neeg mob cov kab mob sib koom ua ke thiab txo cov qib C-reactive protein tab sis kuj txhim khu kev ua haujlwm ntawm kev tswj T hlwb (Treg) hauv cov nas mob caj dab thiab txo qhov tso tawm ntawm cov kab mob inflammatory. Yog li ntawd, kev tswj cov kab mob plab hnyuv tau dhau los ua cov kev taw qhia tshiab hauv kev kho mob caj dab.

Table 1 Kev kho mob rau mob caj dab

3. Mechanism ntawm probiotics tswj kev mob caj dab

Probiotics tuaj yeem txo cov plab hnyuv permeability, cuam tshuam rau lub cev tiv thaiv kab mob, txhim kho qhov distal secretory immunoglobulin A (IgA) lub cev tiv thaiv kab mob, txwv kev loj hlob ntawm cov kab mob kab mob, thiab txo cov tshuaj tiv thaiv kab mob xws li qog necrosis factor (TNF-).

4. Kev rho tawm thiab tshuaj xyuas cov tshuaj probiotics

Cov kab mob muaj txiaj ntsig tau raug cais tawm ntawm cov quav ntawm cov nas noj qab haus huv, thiab 16S rDNA gene sequence tau siv los xyuas kom meej tias cov kab mob tau txais muaj kev nyab xeeb thiab txhim khu kev qha thiab yuav tsis ua mob rau tib neeg lub cev. Los ntawm kev sib piv cov hom kev muaj peev xwm los txo cov qib ntawm cov kab mob cytokines hauv cov ntshav thiab daim siab, Lactobacillus johnsonii LBJ 456 tau kuaj xyuas rau nws lub peev xwm los txo qis kev mob.

5. Taw qhia rau Lactobacillus johnsonii LBJ 456

Kev kawm tiav: ntau dua 10 daim ntawv + 2 US patents + 1 EU patent + 3 Suav patents (tsim los ntawm Hehe Biotech)
Lub peev xwm adhesion yog raws li qhia hauv qab no (hauv vitro monolayer cell adhesion test):

LBJ 456 hlwb muaj adhesion zoo.
Cov txiaj ntsig ntawm 60-hnub ultra-ntev colonization (tib neeg sim) yog raws li nram no:

LBJ 456 tseem tuaj yeem colonize lub cev tom qab 60 hnub ntawm kev noj.
Innate resistance VS tau txais embedding:

Microencapsulation muaj kev tiv thaiv zoo ntawm cov kab mob.

Gastric acid kam rau ua:

Qhov muaj zog gastric acid kam rau ua yog lub hauv paus tseem ceeb rau nws txoj kev ua tiav adhesion thiab colonization. Lub plab acid kam rau Lactobacillus johnsonii LBJ456 thiab lwm yam probiotics tau muab piv rau hauv cov kab mob gastric acid simulated ntawm pH 3, 2, 1.6, thiab 1.2.
Thaum pH thaum kawg mus txog 1.2, txawm hais tias tus naj npawb ntawm Lactobacillus johnsonii LBJ 456 poob los ntawm 3 qhov kev txiav txim ntawm qhov loj, nws yog tib txoj kev muaj sia nyob hauv qhov kev sim.
Mucus binding proteins:

Mucus-binding protein yog ib lub xovtooj ntawm cov protein uas muaj cov teeb liab peptide, uas yog covalently txuas rau cov kab mob ntawm phab ntsa. Nws feem ntau pom muaj nyob rau hauv cov kab mob lactic acid. Nws tuaj yeem khi rau hauv plab hnyuv mucin los ntawm kev hloov kho glycosyl, yog li ua tiav adhesion thiab colonization.
Lactobacillus johnsonii LBJ456 muaj cov MBPs ntau tshaj plaws, uas piav qhia txog qee qhov kev ua kom muaj peev xwm ua kom zoo dua qub ntawm cov kab mob no.

6. Kev txheeb xyuas cov nyhuv anti-inflammatory

Cov kev kho mob ntawm probiotics rau nas nrog mob caj dab yog raws li nram no:

Lactobacillus johnsonii LBJ 456 tuaj yeem txo cov qib ntawm inflammatory cytokines hauv cov ntshav thiab daim siab thaum nce qib ntawm qee yam tshuaj tiv thaiv kab mob hauv daim siab.

NK hlwb (natural killer cells) yog qhov tseem ceeb hauv kev ua rau mob. Lactobacillus johnsonii LBJ 456 kuj tseem tuaj yeem txo tus naj npawb ntawm cov cell killer hauv cov ntshav, tus po, thiab daim siab.

Lactobacillus johnsonii LBJ456 muaj cov nyhuv inhibitory zoo ntawm Escherichia coli, Enterococcus faecalis, thiab Salmonella Enteritidis, thiab tuaj yeem cuam tshuam cov lus teb inflammatory los ntawm cov kab mob pathogenic rau qee yam.

cov ntaub ntawv:

[1] Li Xu, Xu Xu, Xing Weiyao, et al. Tshawb xyuas qhov cuam tshuam ntawm electroacupuncture ntawm cov hnyuv thiab cov kab mob hauv cov hlab ntsha hauv cov luav nrog tus qauv rheumatoid mob caj dab raws li "kab mob plab" axis [J / OL]. Phau ntawv xov xwm suav tshuaj suav tshuaj, 1-8 [2024-01-10] https://doi.org/10.19879/j.cnki.1005-5304.202307047.
[2] Bungau SG, Behl T, Singh A, Sehgal A, Singh S, Chigurupati S, Vijayabalan S, Das S, Palanimuthu VR. Targeting Probiotics hauv Rheumatoid Arthritis. Khoom noj khoom haus. 2021 Sep 26; 13(10):3376. doi : 10.3390/nu13103376. PIB: 34684377; PIB: PMC8539185.
[3] Probiotic Gastrointestinal Transit thiab Colonization Tom Qab Kev Tswj Qhov Ncauj: Ib Txoj Kev Ntev.
[4] Acid, kua tsib, thiab kub kam rau cov kab mob dawb thiab Microencapsulated Probiotic.
[5] Kev soj ntsuam sib piv ntawm cov proteins nrog cov mucus-binding domain pom tsuas yog hauv cov kab mob lactic acid.

7. Kev soj ntsuam ntawm excipients

Mulberries: nplua nuj nyob rau hauv anthocyanins thiab polyphenols, lawv yog ntuj antioxidants. Anthocyanins tuaj yeem cuam tshuam qhov kev qhia ntawm pro-inflammatory cytokines, cell adhesion molecules, thiab oxygen dawb radicals, cuam tshuam rau cov khoom siv hluav taws xob KB thiab mitogen-activated protein kinase txoj hauv kev, kho cov kev qhia ntawm nitric oxide thiab cyclooxygenase 2, thiab siv cov tshuaj tiv thaiv kab mob. . inflammatory nyhuv.
Concanavura: Canana peptide muaj cov nyhuv inhibitory zoo ntawm COX-2. Cyclooxygenase-2 yog cyclooxygenase inducible, thiab nws cov lus qhia tau nce siab-tswj thaum txhawb los ntawm cov teeb meem inflammatory, yog li ua rau cov lus teb inflammatory thiab ua rau cov cell puas. , ua rau cell senescence; cog-derived bioactive peptides tuaj yeem txhim kho o thiab cell senescence los ntawm down-regulating qhia ntawm COX-2 mRNA.
Almonds: Cov tshuaj tiv thaiv kab mob ntawm almonds feem ntau yog vim tsis muaj roj fatty acids, polyphenols, thiab tocopherols muaj nyob rau hauv almond roj. Zorrilla et al. ntseeg hais tias almond roj nplua nuj nyob rau hauv polyphenols yuav induce inflammatory hlwb nyob rau hauv ib tug nas colitis qauv. Infiltration yog txo thiab myeloperoxidase (MPO) kev ua thiab lwm yam enzymes, xws li iNOS, yog inhibited. Kev tshawb fawb los ntawm Muller et al. qhia tau hais tias almond roj nplua nuj nyob rau hauv oleic acid tuaj yeem cuam tshuam kev ua haujlwm ntawm iNOS thiab COX-2, thiab txo cov qib ntawm cov pro-inflammatory cytokine TNF- kom ua tiav cov hom phiaj tiv thaiv.
Inulin thiab fructooligosaccharides: feem ntau siv prebiotics los txhawb kev loj hlob thiab metabolism ntawm probiotics hauv lub cev.

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