Allergic Rhinitis Probiotics Capsules

Khoom npe: Allergy rhinitis probiotics capsules
Khoom specifications: 30 capsules/box
Cov khoom hnyav: 0.5 g / ntsiav tshuaj
Indications: Cov tshuaj muaj pes tsawg leeg muab los ntawm cov khoom no tuaj yeem txo cov tsos mob xws li khaus qhov ntswg, txham, los ntswg, thiab lwm yam., thiab muaj cov txiaj ntsig zoo rau kev ua xua rau rhinitis.
Cov lus qhia rau kev noj: 0.5 g / ntsiav tshuaj, 2 ntsiav tshuaj ib zaug, ib zaug / d.
Txoj kev khaws cia: Khaws rau hauv qhov chaw txias thiab qhuav, zoo dua tso rau hauv tub yees ntawm 4 degree.
Cov kab mob uas muaj peev xwm suav tau: kev sib xyaw probiotic (40 billion CFU/g), Bifidobacterium longum HH-BL18 (10 billion CFU/g), Bifidobacterium lactis HH-BA68 (10 billion CFU/g), Lactobacillus rhamnosus PB-LR76 (10 billion CFU/ g) thiab Lactobacillus reuteri PB-LR09 (10 billion CFU/g).
Lwm cov khoom xyaw: fructooligosaccharides, galactooligosaccharides.

2. Technical keeb kwm
Allergic rhinitis (hypersensitive rhinitis), tseem hu ua allergic rhinitis (AR), yog hais txog ib qho mob uas ib tus neeg raug cuam tshuam los ntawm kev ua xua, feem ntau kho los ntawm immunoglobulin E (IgE), thiab lub cev tiv thaiv kab mob. Nws yog ib tug mob inflammatory kab mob ntawm lub qhov ntswg mucosa nrog cov tsos mob tseem ceeb ntawm episodic txham, los ntswg qhov ntswg, thiab qhov ntswg congestion, nrog rau cytokines thiab lwm yam.
Tam sim no, loratadine feem ntau yog siv los kho cov kab mob rhinitis los txo cov tsos mob xws li txham, qhov ntswg, qhov ntswg qhov ntswg, qhov ntswg congestion, qhov muag khaus, thiab kub hnyiab. Txawm li cas los xij, nws cov txiaj ntsig kho thiab kho tus nqi tsis tseem ceeb. Cov kev tshawb fawb pom tau hais tias ntxiv cov nroj tsuag ib txwm muaj ntawm cov kab mob ua pa kom tsim nyog tuaj yeem tswj hwm qhov sib npaug ntawm cov pa microecology, ua rau nws cov nyhuv antagonistic rau cov kab mob txawv teb chaws, thiab inhibit lawv txoj kev loj hlob. Nyob rau tib lub sijhawm, nws tseem tuaj yeem muab cov cim qhia uas txhawb nqa lub cev tiv thaiv kab mob kom loj hlob thiab cov ntaub so ntswg endothelial sib txawv, txhim kho lub cev tiv thaiv kab mob ua haujlwm.
Kev nce tus naj npawb ntawm probiotics hauv cov kab mob ua pa los tiv thaiv kab mob ua pa thiab txhim kho cov kab mob ua pa yog ib txoj hauv kev tsim nyog rau kev mloog.

3. Mechanism ntawm probiotics txhim kho cov kab mob ua pa
Kev tshawb fawb qhia tau hais tias cov kab mob ua pa sab sauv tuaj yeem ua tiav kev tiv thaiv kab mob thiab txhim kho kev tiv thaiv kab mob los ntawm ntau txoj hauv kev tiv thaiv kab mob: (1) Cov kab mob ua pa sab sauv probiotics muaj peev xwm ua kom muaj peev xwm ua rau lub ntsws sab sauv mucosal epithelial hlwb thiab cuam tshuam kev cuam tshuam ntawm cov kab mob Streptococcus pyogenes thiab tib neeg epithelial hlwb Adhesion tiv thaiv kab mob pathogenic los ntawm invading lub sab sauv kab mob mucosa; (2) Cov kab mob ua pa sab sauv probiotics tsim cov tshuaj tua kab mob txaus txaus, uas tuaj yeem tua cov kab mob pathogenic thiab txo cov kev siv tshuaj tua kab mob; (3) Cov kab mob ua pa sab saud tuaj yeem ua rau lub cev tiv thaiv kab mob tsim cov tshuaj tiv thaiv kab mob tiv thaiv kab mob, ua rau kom muaj cov tshuaj tua kab mob thiab cov kab mob hauv cov qaub ncaug, thiab txo cov kab mob hauv lub cev, yog li ua kom lub cev muaj peev xwm tiv thaiv kab mob thiab kab mob.

4. Hehe Kev Tiv Thaiv Kab Mob thiab Kev Kho Mob ntawm Allergic Rhinitis Strains
Qhov chaw ntawm cov kab mob: cais tawm ntawm cov neeg laus txoj hnyuv, qhov kub ntawm fermentation yog 36-38 degree, lub sij hawm fermentation yog 6-36 teev, thiab kab lis kev cai nruab nrab yog MRS kab lis kev cai nruab nrab los yog hloov kab lis kev cai nruab nrab uas muaj MRS kab lis kev cai nruab nrab. .
Kev txheeb xyuas cov kab mob: cais tawm thiab ntxuav cov kab mob, siv 16S rRNA gene raws li cov cim cim, ua kom nrov ntawm 16S rRNA ib ntus hauv cov noob nrog universal primers, thiab tom qab ntawd ua electrophoresis nrhiav thiab sib piv nrog NT database kom tau txais cov ntaub ntawv hom nrog cov kab ke zoo sib xws. . Nrog kev pab los ntawm homologous Txoj kev sib piv tau pab txiav txim siab hom ntaub ntawv. Qhov kev faib tawm yog hu ua Bifidobacterium longum, thiab tus lej yog HH-BL18.

Kev txuag cov kab mob: Bifidobacterium longum HH-BL18 (Bifidobacterium longum HH-BL18) strain tau muab tso rau hauv Tuam Tshoj Hom Culture Collection Center rau lub Peb Hlis 24, 2022. Qhov chaw nyob qhov tso nyiaj yog No. 299 Bayi Road, Wuchang District, Wuhan City, Hubei Province. . Tus lej tso nyiaj yog CCTCC NO: M 2022306, thiab lub npe kev faib tawm yog Bifidobacterium longum. Bifidobacterium lactis HH-BA68, Lactobacillus rhamnosus PB-LR76 thiab Lactobacillus reuteri PB-LR09 yog txhua yam khoom siv lom neeg uas twb muaj lawm uas tau luam tawm thiab muaj rau pej xeem. Tus neeg thov tau luam tawm cov ntaub ntawv patent xws li Suav patent CN 111500483A thiab Suav patent Luam tawm hauv CN111991428 A, thiab lwm yam., cov ntaub ntawv tso nyiaj dhau los yog: Bifidobacterium lactis HH-BA68 yog muab tso rau hauv Tuam Tshoj Hom Culture Collection Center, thiab tus lej tso nyiaj yog CCTCC NO: M 20211125; Lactobacillus rhamnosus PB-LR76 yog muab tso rau hauv Tuam Tshoj Hom Culture Collection Center, tus lej khaws cia yog CCTCC NO: M2018887; Lactobacillus reuteri PB-LR09 yog muab tso rau hauv Tuam Tshoj Hom Culture Collection Center, tus lej khaws cia yog CCTCC NO: M2018888.

Kev npaj cov kab mob hmoov: Bifidobacterium longum HH-BL18, Bifidobacterium lactis HH-BA68, Lactobacillus rhamnosus PB-LR76, thiab Lactobacillus reuteri PB-LR09 tau inoculated rau hauv MRS kua kab lis kev cai nruab nrab, thiab thaum kawg ntawm nqa tawm cov kev tsim nyog rau fermentation. cov kua probiotic sib raug. Centrifuge tus tau txais fermentation kab mob kua thiab sau cov precipitate kom tau cov kab mob av nkos ntawm plaub yam probiotics. Ntxiv cov tshuaj tiv thaiv kom qhuav kom tsim nyog rau cov kab mob hauv av thiab tom qab ntawd ua lub tshuab nqus tsev kom qhuav kom tau Bifidobacterium longum HH-BL18 cov kab mob hmoov thiab mis nyuj. Bifidobacterium HH-BA68 cov kab mob hmoov, Lactobacillus rhamnosus PB-LR76 cov kab mob hmoov, thiab Lactobacillus reuteri PB-LR09 cov kab mob hmoov.

5. Kev txheeb xyuas cov txiaj ntsig ntawm kev txhim kho cov tsos mob ntawm cov kab mob ua pa
Tsim cov pab pawg qauv: Cov kev sim guinea npua (190 tus neeg laus noj qab haus huv guinea npua, ib nrab txiv neej, thiab poj niam) tau muab faib ua 19 pawg, 10 hauv txhua pab pawg, thawj-chav British yug, hnyav 315 ~ 457 g. 10 μL ntawm 10% TDI txiv roj roj tov tau muab tso rau hauv lub qhov ntswg los tsim cov qauv ntsuas qhov ntswg.
Cov pab pawg sim: pawg tswj tsis pub muaj (cov npua noj qab nyob zoo, tsis muaj tshuaj noj); pawg tswj qauv (sim qauv guinea npua, tsis muaj tshuaj); pab pawg tswj tsis zoo (kev sim ua qauv guinea npua tau muab cov tshuaj tiv thaiv kom qhuav tsis muaj cov khoom xyaw nquag); xeem pawg 1-11, pab pawg tswj 1-5; ntawm lawv, cov khoom xyaw tshwj xeeb ntawm kev xeem pawg 1-11 thiab pawg tswj hwm 1-4 yog raws li qhia hauv cov lus hauv qab no, hauv qhov hnyav (unit: g); tswj pab pawg 5 yog kev lag luam muaj Loratadine.

Faj seeb: "X" sawv cev rau cov lej ntawm cov kab mob ntawm cov kab mob ntawm cov kab mob Bifidobacterium longum HH-BL18 thiab Bifidobacterium lactis HH-BA68; "Y" sawv cev rau cov mis nyuj rhamnosus Cov sum ntawm cov kab mob hmoov feem ntawm Lactobacillus reuteri PB-LR76 thiab cov kab mob hmoov feem ntawm Lactobacillus reuteri PB-LR09; "-" qhia tias nws tsis muaj qhov tseem ceeb ntawm kev suav.

Kev sim txoj kev: Qhov ntswg qhov ntswg khaus, txham, thiab qhov ntswg qhov ntswg tshwm tom qab 6 hnub ntawm kev ua qauv; Tom qab ntawd, pawg tswj hwm dawb huv, pab pawg tswj tsis zoo, thiab pab pawg kuaj tau muab cov tshuaj sib xws 2 mg / kg los ntawm kev tswj hwm intragastric ib hnub ib zaug rau ib lub lis piam. (7 hnub). Tom qab kev tswj hwm, tus guinea npua cov tsos mob ntawm qhov ntswg xws li qhov ntswg khaus, qhov ntswg, thiab txham tau sau tseg thiab lawv qhov hnyav tau sau tseg. Lub sijhawm soj ntsuam yog nyob rau hauv 30 feeb tom qab kev tswj hwm.

Cov txiaj ntsig kev xeem: Cov txiaj ntsig kev xeem tom qab tswj hwm hnub 4 yog qhia hauv cov lus hauv qab no.

Raws li tuaj yeem pom los ntawm lub rooj, hauv cov txiaj ntsig kev xeem tom qab kev tswj hwm hnub 4: cov txiaj ntsig kho mob ntawm pawg xeem 7-11 tau zoo dua li cov khoom lag luam muaj loratadine (tswj pab pawg 5), tshwj xeeb tshaj yog pawg xeem 11 muaj qhov zoo ntawm cov khoom lag luam. zoo tshaj plaws kho nyhuv. Tag nrho cov tsos mob tau ploj mus, thiab cov nyhuv curative sai sai; cov txiaj ntsig kho ntawm pawg xeem 5-6 yog thib ob, uas yog sib npaug rau pawg tswj 5; cov tsos mob ntawm pawg sim 1-4 tau pib txo qis, thiab cov tsos mob ntawm pawg tswj hwm 1-4 tsis tau pom kev txhim kho tseem ceeb.
Thaum kawg ntawm xya hnub ntawm kev tswj hwm, tag nrho cov tsos mob hauv pawg sim 7-11 tau ploj mus, thiab tag nrho cov tsos mob hauv pawg sim 5-6 thiab pawg tswj 5 tau ploj mus; hauv pawg xeem 1-4, cov tsos mob ntawm qhov ntswg me ntsis tseem muaj thiab tsis tshua muaj qhov ntswg khaus, khawb, thiab txham; tag nrho cov tsos mob hauv pawg tswj hwm 1-4 tau kho me ntsis.
Hauv cov ntsiab lus, cov kab mob saum toj no tuaj yeem txo cov tsos mob ntawm qhov ntswg khaus, txham, thiab los ntswg, thiab muaj txiaj ntsig zoo rau kev ua xua rhinitis.

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