Pw tsaug zog pab Probiotics Capsule
Specifications: 0.5g × 60 capsules/box
Formula (cov ntsiab lus ntawm ib ntsiav tshuaj):
Lactobacillus plantarum N{0}}: 50 Billion CFU
Rhamnosus PB-LR76: 30 Billion CFU
Lactobacillus paracasei HH-LP58: 40 Billion CFU
Chamomile: 40 mg, Lemon Balm 40 mg, Passionflower: 40 mg, Ziziphus Seed: 40 mg, Galacto-oligosaccharide: 40 mg
Cov mis probiotic no yog kho los txhawb kev pw tsaug zog. Cov mis probiotic no muaj patented thiab scientifically proven probiotic hom Lactobacillus plantarum N-1 thiab Rhamnosus PB-LR76, uas tau raug tshawb fawb pov thawj rau:
√ Txo kev ntxhov siab
√ Tshem tawm qhov mob
Pom zoo siv thiab ntau npaum li cas: 1 ntsiav tshuaj ib hnub twg, noj qhov ncauj nrog dej sov 30 feeb ua ntej mus pw.
Lus Cim: Kev txhim kho kev pw tsaug zog yog txoj kev mus sij hawm ntev thiab nws raug pom zoo kom noj nws txhua hnub. Tom qab noj nws, thov pw thiab kaw koj lub qhov muag. Tsis txhob ua si nrog koj lub xov tooj ntawm tes, saib TV series, ua si, lossis lwm yam kev coj cwj pwm uas yuav ua rau koj lub hlwb tsis zoo, thiaj li tsis cuam tshuam rau cov nyhuv. Tsis tas li ntawd, sim kho koj cov haujlwm txhua hnub thiab lub sijhawm so, uas tuaj yeem yooj yim tsim lub moos lom neeg zoo nkauj thiab ua kom ntev lub sijhawm pw tsaug zog. Cov nyhuv ntawm kev txhim kho kev pw tsaug zog zoo dua.
Txoj kev cia: Khaws rau hauv qhov chaw txias, nyiam dua ntawm 4 degree.
Lub neej txee: 24 lub hlis
Cov txheej txheem uas cov hnyuv muaj feem xyuam rau kev pw tsaug zog
Raws li kev tshawb fawb ntawm lub plab-hlwb axis mechanism nyob rau hauv kaum xyoo dhau los los yog li ntawd, cov kws tshawb fawb tau pom tias cov kab mob hauv plab tuaj yeem cuam tshuam rau kev pw tsaug zog los ntawm plaub txoj hauv qab no:
1. Txoj kev tiv thaiv kab mob
Ob lub hlwb thiab plab microbiomes cuam tshuam rau kev ua haujlwm ntawm lub cev tiv thaiv kab mob thiab, dhau los, cuam tshuam ib leeg. Cov kab mob hauv plab yog engulfed thiab zom los ntawm phagocytes (xws li macrophages lossis neutrophils); cov khoom siv digestive (xws li MPs (mononuclear phagocyte system), LPS (cov kab mob lipopolysaccharide)) raug tso tawm rau hauv cov kua dej nyob ib puag ncig. MPs thiab LPS nyob rau hauv lem qhib phagocytes, uas ces tso cytokines.
2. Neuroendocrine txoj kev
Muaj ntau tshaj 20 hom kab mob enteroendocrine hauv cov hnyuv, ua rau cov kab mob endocrine loj tshaj plaws. Lub plab microbiota yog koom tes ncaj qha rau hauv kev tsim ntau yam neurotransmitters, cytokines, thiab metabolites, xws li 5-HT (serotonin), dopamine, gamma-aminobutyric acid (GABA), SCFA (short-chain fatty acids), thiab Melatonin Hormones, thiab lwm yam. Tej yam Lactobacilli thiab Bifidobacteria tuaj yeem tsim GABA. Kev qhia txawv txav ntawm GABA mRNA feem ntau pom nyob rau hauv cov neeg mob insomnia. E. coli tsim norepinephrine, serotonin, thiab dopamine; Streptococcus thiab Enterococcus tsim serotonin; thiab Bacillus tsim norepinephrine thiab dopamine. Cov kab mob muaj txiaj ntsig yog koom nrog hauv kev tso tawm cov tshuaj hormones, uas ua rau qaug zog. Tryptophan nyob rau hauv cov amino acid yog ib qho tseem ceeb raw khoom rau synthesis ntawm melatonin vim peb lub cev tsis tuaj yeem tsim nws tus kheej thiab yuav tsum tau txais los ntawm cov khoom noj. Cov protein nyob rau hauv cov zaub mov kuj yuav tsum tau tawg mus rau hauv tryptophan los ntawm cov kab mob hauv cov hnyuv. Tryptophan cov ntaub ntawv 5-hydroxytryptamine, uas yog ces thauj mus rau lub hlwb thiab hloov mus rau hauv cov neurotransmitter serotonin. Serotonin yuav tsim cov tshuaj hormone melatonin. Yog li, yog tias cov kab mob hauv cov hnyuv tsis tuaj yeem ua haujlwm li qub, lawv yuav cuam tshuam rau kev tso tawm ntawm melatonin, ua rau tsis muaj kev pw tsaug zog.
3. Hypothalamic-pituitary-adrenal (HPA) axis txoj kev
HPA axis koom nrog hauv homeostasis thiab cov lus teb rau cov stimuli tshiab. HPA axis yog ib qho kev hloov kho uas tsim los tswj cov homeostasis hauv qhov chaw hloov pauv. Kev loj hlob lub cev ntawm kev tshawb fawb qhia txog kev sib raug zoo ntawm kev pw tsaug zog thiab HPA axis kev ua haujlwm. Hyperactivity ntawm HPA axis tuaj yeem cuam tshuam tsis zoo rau kev pw tsaug zog, ua rau kev pw tsaug zog tsis sib haum, txo qis kev pw tsaug zog qeeb qeeb, thiab pw tsaug zog ntev. Nyob rau hauv lem, kev pw tsaug zog tsis zoo nrog rau insomnia thiab obstructive pw tsaug zog apnea tuaj yeem ua rau HPA axis ua haujlwm tsis zoo.
4. Vagus hlab ntsha txoj kev
Kev hnov mob neurons ntawm myenteric plexus koom nrog lub plab microbiota los ntawm kev tswj cov hnyuv motility thiab plab hnyuv cov tshuaj hormone secretion. Kev hnov mob neurons ntawm myenteric plexus koom nrog lub plab microbiota los ntawm kev tswj cov hnyuv motility thiab plab hnyuv cov tshuaj hormone secretion. Lub paj hlwb enteric kuj tsim synaptic kev sib txuas nrog lub paj hlwb vagus, uas txuas lub plab mus rau lub hlwb. Cytokines teeb liab rau lub hlwb ntawm vagal afferents, thiab kev ua tau zoo los ntawm cov hlab ntsha vagus ntxiv induce glial hlwb thiab neurons los tsim cytokines hauv lub hlwb. Qib ntawm cytokine concentration yog cuam tshuam nrog kev pw tsaug zog. Tsawg concentrations ntawm lub paj hlwb cytokines tuaj yeem txhawb kev pw tsaug zog, thaum lub hlwb cytokines siab ntau ua rau pw tsaug zog.
Mechanism ntawm kev ua ntawm probiotics
1. Koom nrog kev tiv thaiv kab mob
Probiotics tuaj yeem tsim ntau yam cytokines thiab chemokines nyob rau hauv lub cev thiab hloov peripheral inflammatory markers thiab lub cev tiv thaiv kab mob. Lub plab hnyuv microbiota cuam tshuam nrog lub cev tiv thaiv kab mob hauv lub hlwb, yog li cuam tshuam rau qib ntawm cytokines, cell motility teb yam, thiab prostaglandin E2, cuam tshuam rau lub cev tiv thaiv kab mob ntawm lub paj hlwb, tswj lub hlwb kev ua si, thiab ua tiav cov txiaj ntsig ntawm kev txhawb pw tsaug zog.
2. Koom nrog kev tswj hwm endocrine
Probiotics tuaj yeem hloov pauv cov neurotransmitters hauv nruab nrab los ntawm kev hloov pauv cov qib precursor ntawm central neurotransmitters. Probiotics tseem tuaj yeem ncaj qha ua ke thiab tso tawm cov neurotransmitter -aminobutyric acid (GABA). (GABA) yog ib qho tseem ceeb inhibitory neurotransmitter hauv tib neeg lub paj hlwb. Nws tuaj yeem cuam tshuam qhov kev zoo siab ntawm lub paj hlwb sympathetic thiab ua raws li tus neeg sawv cev hypnotic. , sedation, thiab lwm yam teebmeem.
3. Tswj HPA axis thiab txo cov kev zoo siab thaum hmo ntuj
Probiotics thiab prebiotics tuaj yeem ua rau cov kab mob hauv plab hnyuv los tswj cov cim neural hauv hypothalamic-pituitary-adrenal (HPA) axis los ntawm cortisol.
Lactobacillus plantarum N-1[2]
Qhov chaw ntawm cov kab mob: Yak cheese los ntawm Qinghai-Tibet Plateau
Tus lej sau: CGMCC No.15463
Acid thiab bile ntsev kam rau ua [3]
Acid thiab bile kam rau ua yog cov khoom tseem ceeb tshaj plaws ntawm probiotics vim tias lawv txiav txim siab lawv lub peev xwm kom muaj sia nyob hauv cov hnyuv me thiab yog li siv lawv lub luag haujlwm ua probiotics. N-1 pom tau tias muaj sia nyob zoo heev ntawm pH qis thiab siab siab ntsev ntsev concentration.
Adhesion [4]
Kev muaj peev xwm ua raws li tus tswv tsev yog qhov tseem ceeb rau kev tshuaj xyuas cov muaj peev xwm probiotics. Nws tau xav tias yuav cuam tshuam nrog kev colonization, kev tiv thaiv kab mob, kev tiv thaiv kev tiv thaiv kab mob, thiab kev txhim kho ntawm kev ua haujlwm tsis zoo. Cov txiaj ntsig ntawm adhesion test tau pom tias cov adhesion naj npawb ntawm N-1 rau Caco-2 hlwb yog 6.04 × 106 CFU/mL, thiab tus nqi adhesion yog 4.03%.
Lus Cim: Tus qauv Caco-2 cell yog ib tug tib neeg cloned colon adenocarcinoma cell. Nws cov qauv thiab kev ua haujlwm zoo ib yam li qhov sib txawv ntawm cov hnyuv me me epithelial hlwb. Nws muaj cov qauv xws li microvilli thiab muaj cov enzyme systems uas cuam tshuam nrog txhuam ciam teb epithelium ntawm txoj hnyuv me. Nws tuaj yeem siv los ua kev sim simulating plab hnyuv thauj hauv vivo.
Kev sim pw tsaug zog pab cuam
Tsib caug nas, hnyav 18-22g, tau muab faib ua 5 pawg, xws li Piv txwv 1-3 pawg, pawg tswj hwm dawb huv, thiab pawg tswj hwm zoo. Muaj 10 nas nyob rau hauv txhua pawg, ib nrab txiv neej thiab ib nrab poj niam, thiab txhua pab pawg tau tswj hwm intragastrically. Cov koob tshuaj intragastric tau raws li hauv qab no: Piv txwv 1-3 tau muab 2g / kg ntawm kev pw tsaug zog probiotic muaj pes tsawg leeg; pab pawg tswj xyuas zoo tau tswj hwm 2g / kg ntawm jujube kernel extract (yuav los ntawm Guangzhou Hecheng Sanxian Biotechnology Co., Ltd.); thiab kev tswj hwm dawb huv tau tswj hwm. Tib tus nqi ntawm ib txwm saline tau muab rau cov pab pawg. Thawj zaug ib hnub rau 1 lub lis piam. Ib lub lim tiam tom qab, lub koob yees duab saib xyuas tau siv los soj ntsuam thiab sau tseg: kev pw tsaug zog ntawm txhua pawg nas tom qab 30 feeb ntawm kev tswj hwm intragastric; lub sij hawm pw tsaug zog ntawm txhua pab nas nyob rau hauv 12 teev tom qab kawg ntawm intragastric tswj, thiab cov theem ntawm 5-HT thiab 5-HT nyob rau hauv lub hlwb ntawm txhua pawg nas raug ntsuas. GABA cov ntsiab lus.
Cov nas nyob rau hauv pab pawg probiotic noj txhua hnub tau muaj txiaj ntsig zoo rau kev pw tsaug zog, thiab qib GABA thiab 5-HT (5-}hydroxytryptamine) hauv lub hlwb tau nce ntau.
Kev ntsuas lub xeev tom qab pw tsaug zog
Peb caug tus qauv kev nyuaj siab nas tau muab faib ua ob pawg. Pab pawg tswj hwm tau pub noj zaub mov zoo tib yam, thiab pab pawg sim tau pub pub noj uas muaj probiotics. Lwm yam kev pub mis yog tib yam. Cov qhabnias tom qab pw tsaug zog ntawm ob pawg nas tau ntsuas rau 7 lub lis piam los sim ua tib neeg tom qab pw tsaug zog rov qab los ntawm kev ntxhov siab ntev. Lub sijhawm pw tsaug zog txhua lub lim tiam thiab lub sijhawm pw tsaug zog hauv 6 lub lis piam tom ntej tau muab piv thiab ntsuas.
Cov txiaj ntsig tau pom tias kev noj qab haus huv ntawm cov nas hauv pab pawg probiotic tau txhim kho zoo tom qab pw tsaug zog, thiab lawv lub xeev rov qab los tom qab pw tsaug zog kuj tseem txhim kho. Ntxiv mus, qhov pw tsaug zog latency ntawm nas noj probiotics tau luv los ntawm 18.8%, thiab lub sijhawm pw tsaug zog tau nce 7.2%.
Kev ntsuam xyuas pw tsaug zog zoo
N-1 tuaj yeem txhim kho kev ntxhov siab, kev ntxhov siab, thiab kev nyuaj siab zoo li tus cwj pwm hauv cov nas autistic
Raw khoom los ntawm tib lub hauv paus chiv keeb li tshuaj thiab zaub mov:
Chamomile: German Chamomile (German Chamomile) yog nyob rau teb chaws Europe thiab belongs rau genus Matricaria ntawm tsev neeg Asteraceae. Nws yog ib qho overwintering txhua xyoo tshuaj ntsuab. Lub inflorescence muaj ib lub teeb kua tshuaj tsw qab thiab muaj cov teebmeem ntawm kev txhim kho pw tsaug zog, calming mus ob peb vas, nourishing lub siab, thiab txo cov ntshav siab.
Txiv qaub balm: Nyob rau hauv pharmacopeia thiab tshuaj tsoos tshuaj, txiv qaub balm yog siv los kho cov kab mob plab hnyuv thiab ua sedative los kho mob pw tsaug zog; Hauv pej xeem cov tshuaj, nws yog siv los kho hnoos, kiv taub hau, dysmenorrhea, kab mob ntawm daim tawv nqaij, thiab raws li ib tug sedative, Antispasmodic, antiseptic.
Passionflower: Passionflower extract txhim kho affinity rau GABA receptors thiab inhibits GABA reuptake hauv nas cortical synaptosomes; induces ncaj qha GABA tam sim no nyob rau hauv CA1 hippocampal pyramidal neurons, zoo ib yam li cov tshuaj benzodiazepines.
Ziziphus noob: Ziziphus noob muaj ntau yam khoom xyaw xws li alkaloids, saponins, thiab flavonoids. Nws muaj cov teebmeem sedation, hypnosis, analgesia, anti-convulsant, txo cov ntshav lipids, anti-platelet aggregation, txhim khu kev tiv thaiv kab mob, txo cov ntshav siab, anti-hypoxia, anti-myocardial ischemia, anti-arrhythmia, anti-aging, thiab tiv thaiv hluav taws xob.
Cov ntawv & Patents
[1] Qiu Z, et al. (2023) Lactiplantibacillus plantarum N-1 txhim kho tus cwj pwm zoo li autism thiab plab microbiota hauv cov nas. Frontiers hauv Microbiology. DOI 10.3389/fmicb.2023.1134517 IB
[2] Sen, Paromita, et al. "Microbiota thiab pw tsaug zog: awakening lub plab." Trends in molecular Medicine vol. 27,10 (2021): 935-945. doi: 10.1016/j.molmed.2021.07.004
Cim npe nrov: pw pab probiotics, manufacturers, hoobkas, kev cai, wholesale, bulk
