Science thiab Technology Innovation Center Guo Yongjie Kaum Ob Hlis 29, 2023
Cov tsos mob tseem ceeb ntawm kev noj zaub mov muaj xws li plab plab, quav qhuav, lossis qaub tsw. Probiotics tuaj yeem txo cov khoom noj. Probiotics tuaj yeem ntxiv thiab tswj cov hnyuv, pab txhim kho plab hnyuv tiv thaiv kab mob, inhibit plab hnyuv kab mob, txhim kho txoj hnyuv ib puag ncig, thiab txhawb txoj hnyuv ua haujlwm, yog li txhawb kev zom thiab nqus, thiab tseem tuaj yeem kho cov zaub mov ua decomposer.
Tam sim no, cov txheej txheem tseem ceeb koom nrog hauv probiotics txhim kho cov khoom noj muaj xws li hauv qab no:
1. Probiotics tswj lub cev tiv thaiv kab mob
Probiotics tuaj yeem ua rau cov neeg tua neeg ntawm tes cytotoxicity thiab macrophage phagocytosis, ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob hauv lub cev, thiab kho kom haum xeeb los ntawm kev sib cuam tshuam nrog cov enterocytes thiab dendritic hlwb, Th1, Th2, thiab Treg cell lub cev tiv thaiv kab mob. Qee cov probiotics tuaj yeem txhim kho qib ntawm cov tshuaj tiv thaiv kab mob, txhim kho kev tiv thaiv kab mob, thiab txhim kho cov tshuaj tiv thaiv. Probiotic hom tuaj yeem nce qib ntawm cov tshuaj tiv thaiv cytokines xws li IL-10, txo cov qib inflammatory cytokines xws li TNF-, IL-1 , thiab IL-8, thiab muaj qhov tseem ceeb. cuam tshuam rau kev txo cov plab hnyuv o thiab txhim kho colitis.
2. Probiotics txhawb kev tsim cov roj ntsha luv luv
Lactic acid thiab acetic acid uas tsim los ntawm Lactobacilli thiab Bifidobacteria yog cov khoom lag luam kawg ntawm carbohydrate metabolism. Cov organic acids no, thaum tsim nyob rau hauv situ, tuaj yeem txo qis pH intraluminal thiab inhibit qhov kev loj hlob ntawm cov kab mob pathogenic. Txawm hais tias cov kab mob lactic acid thiab bifidobacteria tsis tsim cov butyrate, lawv tuaj yeem nce qib ntawm butyric acid thiab lwm cov kab mob luv luv fatty acids hauv cov hnyuv los ntawm kev sib cuam tshuam nrog lwm cov tsiaj muaj txiaj ntsig (xws li Faecalibacterium), uas tuaj yeem cuam tshuam rau cardiometabolic, hlwb- plab. kev sib cuam tshuam, thiab lwm yam. Physiological functions.
3. Kev sib cuam tshuam ntawm cov tshuaj probiotics thiab cov hnyuv
Probiotics cuam tshuam nrog plab hnyuv los ntawm kev sib tw noj zaub mov, kev tawm tsam, thiab kev sib koom tes. Cov nyhuv antagonistic ntawm probiotics ntawm lwm cov kab mob tej zaum yuav tshwm sim los ntawm lawv cov metabolism ntawm carbohydrates los tsim cov organic acids los yog cov kab mob toxins. Cov tshuaj tua kab mob no tuaj yeem ua haujlwm tawm tsam cov kab mob hauv ntau qhov chaw, suav nrog tib neeg cov zis thiab cov hnyuv. Bifidobacteria tsim acetate thiab muab lub zog rau lwm cov tswv cuab ntawm lub plab microbiota. Cov kev tshawb fawb tau pom tias txawm tias Phobacterium longifolia AH1206 thiab Bifidobacterium ATCC15696 hom tau raug pov thawj tias muaj nyob hauv cov hnyuv ntawm cov menyuam mos, tsis muaj kev sib raug zoo ntawm qhov txo qis ntawm cov kab mob pathogenic thiab cov kab mob co toxins. Lub peev xwm ntawm qee yam probiotics txhawm rau tshem tawm H. pylori tuaj yeem cuam tshuam nrog kev cuam tshuam ntawm cov kab mob, yog li cov probiotics yuav txo qis cov tshuaj tua kab mob.
4. Kev sib cuam tshuam ntawm probiotics thiab tus tswv tsev
Probiotics cuam tshuam nrog tus tswv tsev los ntawm cov xov tooj ntawm tes macromolecules xws li pili thiab mucin-binding proteins. Tsis tas li ntawd, probiotic cell phab ntsa Cheebtsam, xws li lipoteichoic acid thiab peptidoglycan, ua lub luag haujlwm tseem ceeb hauv kev sib cuam tshuam ntawm probiotic-host. Cov kev tshawb fawb tau pom tias cov qauv no hloov pauv kev sib xyaw ntawm lub cev tiv thaiv kab mob, mucin, thiab cov kab mob hauv plab hnyuv epithelial, ua rau lub sijhawm ntev ntawm txoj hnyuv thiab ua kom muaj kev ncaj ncees ntawm txoj hnyuv. Lactobacillus rhamnosus GG thiab GR-1 ua raws cov plab hnyuv epithelium los ntawm cov cell nto macromolecules nrog cov qauv sib txawv, xws li exopolysaccharides, ua kom muaj kev ncaj ncees ntawm txoj hnyuv.
5. Probiotics txhawb kev tsim cov enzymes
Microbial enzymes tsim thiab xa los ntawm qee cov kab mob probiotic, xws li beta-galactosidase thiab kua tsib ntsev hydrolase, txhim kho lactose digestion thiab ntshav lipid profile hauv tib neeg. Noj Streptococcus thermophilus hauv yogurt ua piv txwv, nws tuaj yeem txhawb kev zom zaub mov ntawm lactose. Ntawd yog, tom qab Streptococcus thermophilus nkag mus rau hauv cov hnyuv me, nws nkag mus los ntawm cov kua tsib acids thiab txhawb nqa kev thauj cov microbial -galactosidase mus rau hauv cov hnyuv me, yog li rhuav tshem lactose mus rau hauv yooj yim digested qabzib thiab galactose.