Lactobacillus rhamnosus, hu uaLGG, belongs rau genus Lactobacillus thiab yog ib qho ntawm cov nroj tsuag ib txwm muaj ntawm peb tib neeg lub cev. Nws feem ntau muaj nyob rau hauv lub qhov ncauj thiab txoj hnyuv, tiam sis feem ntau yog faib nyob rau hauv tib neeg txoj hnyuv.Lactobacillus rhamnosusyog ib qho anaerobic, acid-resistant, non-spore-forming probiotic. Nws Gram stain yog ntshav, yog li nws kuj yog kab mob Gram-zoo. Cov txiaj ntsig tseem ceeb ntawm Lactobacillus rhamnosus suav nrog txhim kho txoj hnyuv mucosal barrier, tswj lub cev tiv thaiv kab mob, tiv thaiv kab mob pathogenic, pab zom zaub mov, txo cov ntshav lipids, thiab tiv thaiv daim siab.
1. Txhim kho lub plab hnyuv mucosal barrier:Raws li ib txwm muaj, cov kab mob microbial hauv tib neeg lub cev yog qhov ruaj khov. Tom qab Lactobacillus rhamnosus colonizes thiab reproduces nyob rau hauv txoj hnyuv, nws tsuas yog txuas mus rau lub plab hnyuv epithelial hlwb, thiab muaj peev xwm tsim ib tug lom barrier rau lub plab hnyuv mucosa, li no pab txhawb lub plab hnyuv mucosal barrier muaj nuj nqi ntawm tib neeg lub cev;
2. Tswj lub cev tiv thaiv kab mob:Lactobacillus rhamnosustuaj yeem qhib cov macrophages, thiab nce kev ua haujlwm ntawm cov tshuaj tua kab mob ntuj tsim thiab qib ntawm immunoglobulins, yog li txhim kho cov tshuaj tiv thaiv kab mob tsis tshwj xeeb thiab cov tshuaj tiv thaiv kab mob tshwj xeeb. Tsis tas li ntawd, Lactobacillus rhamnosus thiab nws cov phab ntsa ntawm tes tuaj yeem txhawb kev tso tawm ntawm -tumor necrosis factor, interleukin -6, thiab interleukin -10 los ntawm peripheral ntshav mononuclear hlwb, yog li txhim kho lub cev tiv thaiv kab mob;
3. Antagonizing cov kab mob pathogenic:Lactobacillus rhamnosus tuaj yeem tsim cov lactic acid hauv txoj hnyuv, uas tuaj yeem txo cov haujlwm ntawm cov kab mob xws li Salmonella, Escherichia coli, thiab Staphylococcus hauv cov hnyuv thiab cov haujlwm ntawm cov kab mob phem enzymes, yog li inhibiting kev loj hlob ntawm cov kab mob no. Cov protein secreted los ntawm Lactobacillus rhamnosus tseem tuaj yeem txhawb kev sib npaug ntawm cov plab hnyuv epithelial thiab muaj kev tiv thaiv kab mob hauv plab los ntawm cytokines;
4. Pab digestion:Vim tias Lactobacillus rhamnosus tuaj yeem tso cov lactic acid, nws txhawb cov kua qaub hauv plab, tso cai rau cov zaub mov kom zoo dua absorbed thiab digested;
5. Txo cov ntshav lipids:Lactobacillus rhamnosus tuaj yeem cuam tshuam qhov nqus ntawm cov cholesterol, yog li nws tuaj yeem ua lub luag haujlwm hauv kev txo cov ntshav lipids;
6. Tiv thaiv lub siab: Lactobacillus rhamnosus muaj kev tiv thaiv ntawm cawv ua rau lub siab puas tsuaj, thiab txo cov cawv ua rau lub siab los ntawm kev txo cov oxidative kev nyuaj siab thiab kho cov hnyuv. Tsis tas li ntawd, Lactobacillus rhamnosus muaj cov nyhuv degradation zoo ntawm aflatoxin B1.