Probiotics yog ib hom kab mob nquag uas muaj txiaj ntsig zoo rau tib neeg kev noj qab haus huv. Txij li thaum cov kab mob no muaj kev nkag siab zoo rau ib puag ncig sab nraud, cov teeb meem xws li kev muaj sia nyob tsawg lossis kev ua tsis zoo ntawm cov kab mob lom neeg feem ntau tshwm sim thaum lub sijhawm tsim khoom, khaws cia, thiab siv, uas txo qis cov nyhuv probiotics ntawm probiotics. Encapsulation thev naus laus zis tuaj yeem tiv thaiv probiotics los ntawm ib puag ncig thiab muaj feem cuam tshuam rau qee yam thiab muaj txiaj ntsig zoo ntawm probiotics tiv thaiv cov xwm txheej sab nraud. Nyob rau hauv xyoo tas los no, txoj kev loj hlob sai ntawm probiotic encapsulation technology tau muab lub tswv yim zoo rau kev tiv thaiv zoo ntawm probiotics. Tam sim no, cov thev naus laus zis thev naus laus zis rau encapsulating probiotics feem ntau suav nrog plaub hom: endogenous emulsification method, Pickering emulsification method, composite coagulation method, thiab multi-layer embedding method. Ntawm lawv, multi-layer embedding tshuab feem ntau suav nrog ob txheej txheej embedding thiab peb-txheej embedding. Nrog rau kev ua kom zoo ntawm cov txheej txheem, plaub-txheej embedding thev naus laus zis tau maj mam dhau los ua qhov kev tshawb fawb hotspot.
Txog rau tam sim no, lub ntsiab lus ntawm ntau qhov sib txawv particle complex yog plaub-txheej qauv uas muab kev tiv thaiv siab tshaj plaws rau encapsulated probiotics. Cov plaub-txheej uas siv rau encapsulation tuaj yeem ua rau nws tus kheej los ntawm txheej txheej, lossis nws tus kheej tuaj yeem ua ke nrog microencapsulation tshuab. ua ke. Lactobacillus valericum tau encapsulated nyob rau hauv plaub-txheej hais siv zoo chitosan thiab tsis zoo nqi sodium phytate, thiab cov ciaj sia taus ntawm cov kab mob probiotic nyob rau hauv ob-txheej thiab plaub-txheej qauv nyob rau hauv simulated gastrointestinal kua tau txiav txim. Cov txiaj ntsig tau pom tias hauv cov kua txiv hmab txiv ntoo (pH 1.5) thiab cov kua ntsev ntsev (pH 6.8), tus naj npawb ntawm cov kab mob uas siv tau rau hauv plaub txheej yog ob zaug siab dua li ntawm ob txheej. Hauv ob txoj kev daws teeb meem no, Qhov laj thawj rau qhov txo qis ntawm kev ciaj sia ntawm probiotics embedded nyob rau hauv plaub txheej tej zaum yuav muaj feem xyuam rau lub thickness ntawm cov txheej. Yog li ntawd, txhawm rau ua kom muaj sia nyob ntau dua ntawm probiotics, txoj kev emulsification yuav siv tau los encapsulate cov probiotics nyob rau hauv alginate hais, thiab ces cov particles yog deposited txheej txheej los ntawm chitosan-alginate-chitosan. Ua tiav lub hom phiaj ntawm plaub txheej txheej. Ib qho alginate hais thiab plaub-txheej microparticles tau sim hauv cov kua uas simulated lub plab hnyuv ib puag ncig hauv vitro, thiab qhov muaj txiaj ntsig ntawm probiotics tau ntsuas. Cov txiaj ntsig tau pom tias plaub-txheej encapsulated probiotics tsis tsuas yog txhim kho qhov muaj txiaj ntsig ntawm probiotics, tab sis kuj txhim kho cov haujlwm metabolic ntawm probiotics thaum lub qhov ncauj nqus, nkag mus rau hauv plab hnyuv, thiab thauj mus rau ileum thiab txoj hnyuv.
Plaub-txheej microcapsule encapsulation thev naus laus zis muab lub platform tshwj xeeb rau kev xa cov probiotics mus rau txoj hnyuv, tab sis kev saib xyuas yuav tsum tau ua kom lub thickness ntawm encapsulation yuav tsum tsis txhob siab dhau, txwv tsis pub, nws yuav ncua lub sij hawm lag thiab cuam tshuam nrog kev loj hlob. dynamics ntawm probiotics.
cov ntaub ntawv:
[1] Chen Xu, Zhang Xiaocong, Yuan Haibin, et al. Probiotic encapsulation cutting-edge technology thiab kev tshawb fawb nce qib [J]. Suav Journal of Food Science, 2023, 23(01): 384-396. DOI: 10.16429/j.1009-7848.2023. 01.037 ib.
[2]Sepehr T, Timothy S, Peter V, Aaron S, John MK, Qayyum A, Fariba D, 2022. Biopolymer-Based Multilayer Microparticles for Probiotic Delivery to Colon. Advanced Healthcare Materials, 11, 2102487. DOI: 10.1002/adhm .202102487.