Science thiab Technology Innovation Center Yue Weifeng Kaum Ob Hlis 29, 2023
Lactobacillus reuteri tau raug cais tawm thawj zaug hauv xyoo 1962. Nws yog ib qho probiotic uas tau ua tiav kev tshawb fawb dav dav thiab tuaj yeem ua nyob rau ntau qhov chaw xws li tib neeg lub plab zom mov, qhov zis, thiab tawv nqaij.
Lactobacillus reuteri tuaj yeem tso cov tshuaj tua kab mob, tiv thaiv kev cuam tshuam ntawm cov kab mob pathogenic rau hauv tib neeg lub cev, thiab muaj ntau yam txiaj ntsig kev noj qab haus huv.
Lactobacillus reuteri belongs rau lub genus Lactobacillus, uas kuj muaj xws li Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus bulgaricus, thiab lwm yam, tag nrho cov uas yog probiotics. Ob qho tib si kev tshawb fawb tsiaj thiab kev tshawb fawb soj ntsuam tau pom tias Lactobacilli tuaj yeem pab tiv thaiv thiab kho cov kab mob hauv plab, nrog rau cov kab mob hauv plab, tshuaj tua kab mob raws plab, enteritis, mob qog noj ntshav, thiab mob plab plob tsis so tswj. Ntxiv nrog rau cov kab mob hauv plab hnyuv, Lactobacillus tseem tuaj yeem ua lub luag haujlwm noj qab haus huv hauv lwm qhov ntawm tib neeg lub cev, suav nrog kev tiv thaiv thiab kho cov kab mob ntawm cov poj niam genitourinary, tiv thaiv kev ua xua zaub mov thiab kab mob hniav, thiab lwm yam.
plab hnyuv colonization
Probiotics yuav tsum muaj peev xwm tshwj xeeb, suav nrog kev muaj peev xwm ciaj sia nyob rau hauv qhov sib txawv pH qhov tseem ceeb thiab enzyme-nplua nuj ib puag ncig; muaj peev xwm ua raws li qhov chaw epithelial thiab cuam tshuam nrog tus tswv tsev; sib tw nrog cov kab mob pathogenic; thiab muaj kev nyab xeeb thiab muaj txiaj ntsig.
Txhawm rau zom thiab nqus cov zaub mov hauv plab hnyuv, lub plab secretes gastric acid nrog pH tsawg heev, thiab tseem muaj cov kua tsib ntsev nyob rau sab sauv ntawm txoj hnyuv me, uas ua rau muaj kev phom sij heev rau kev ciaj sia ntawm cov kab mob. Ib qho ntawm cov yam ntxwv ntawm probiotics yog tias lawv tuaj yeem hloov mus rau qhov chaw nyob hauv plab hnyuv, muaj sia nyob hauv tib neeg lub cev, thiab ua kom muaj kev noj qab haus huv. Cov kev tshawb fawb tau pom tias ntau hom Lactobacillus reuteri tiv taus cov pH qis thiab cov kua tsib ntsev, ua rau lawv muaj sia nyob thiab ua rau muaj txiaj ntsig zoo ntawm txoj hnyuv.
muaj txiaj ntsig metabolites
Lactobacillus reuteri lub peev xwm los tiv thaiv kab mob tsis zoo thiab tswj kev tiv thaiv kab mob cuam tshuam nrog cov metabolites nws tsim. Lactobacillus reuteri tsim reuterin, ib qho tshuaj tua kab mob uas cuam tshuam kev loj hlob ntawm ntau yam kab mob, feem ntau yog kab mob Gram-negative, hauv tib neeg lub cev.
Cov khoom ntawm Lactobacillus reuteri kuj muaj xws li lactic acid, acetic acid, thiab lwm yam khoom, uas tuaj yeem pab lub cev tiv thaiv ntau yam kab mob hauv plab, nrog rau Helicobacter pylori, Escherichia coli, Clostridium difficile thiab Salmonella. Kev kis kab mob Helicobacter pylori yog qhov ua rau mob plab thiab mob plab thiab tseem yog ib qho tseem ceeb ua rau mob qog noj ntshav. Qee cov kev tshawb fawb ntseeg tias Lactobacillus reuteri ua los ntawm kev sib tw nrog Helicobacter pylori thiab inhibiting nws txoj kev khi rau glycolipid receptors, yog li txo cov load ntawm Helicobacter pylori hauv lub cev, yog li txo cov tsos mob.
Candida yog ib hom kab mob sib sib zog nqus ntawm cov kab mob fungal uas tuaj yeem nkag mus rau ntawm daim tawv nqaij, mucous daim nyias nyias, thiab cov kab mob hauv nruab nrog cev, tshwm sim ua mob, subacute, lossis mob ntev. Lactobacillus reuteri muaj cov tshuaj tua kab mob uas tuaj yeem tiv thaiv thiab tiv thaiv ntau yam kab mob Candida thiab pab lub cev tshem tawm cov kab mob Candida no.
Tswj poj niam vaginal flora
Lactobacilli dominate qhov chaw mos flora ntawm cov poj niam noj qab haus huv. Ib txoj kev tshawb fawb tau pom tias kev tswj hwm qhov ncauj ntawm Lactobacillus reuteri tsuas yog 14 hnub rov qab los ntawm qhov chaw mos ntawm cov poj niam postmenopausal. Cov txheeb ze ntau ntawm Lactobacilli hauv cov neeg mob uas muaj kab mob vaginosis yog qhov tsawg. Ib txoj kev tshawb fawb luam tawm xyoo 2015 tau pom tias kev tswj hwm qhov ncauj ntawm cov khoom siv probiotic uas muaj Lactobacillus reuteri rau ntau tshaj 4 lub lis piam tuaj yeem ua rau muaj ntau ntawm Lactobacilli hauv cov neeg mob. Txo cov tsos mob ntawm o.
poob phaus
Hauv kev soj ntsuam randomized, ob-dig muag, tshuaj placebo-tswj tshuaj, noj Lactobacillus reuteri rau 12 lub lis piam txo lub cev hnyav hauv cov neeg laus rog. Hauv kev sim nas, tus khub Lactobacillus reuteri no kuj muaj txiaj ntsig los tiv thaiv qhov hnyav nce hauv nas noj cov zaub mov muaj roj.