Probiotics rau poob phaus
Kev rog rog yog ib hom kab mob metabolic uas cuam tshuam rau kev noj qab haus huv thiab ua rau lub neej luv. Yog li ntawd, nws yog ib qho tsim nyog los tsim cov tswv yim zoo los tiv thaiv thiab kho kev rog. Txawm hais tias ntau qhov kev tshawb fawb tau pom tias plab dysbiosis cuam tshuam nrog kev rog, txawm tias hloov plab hnyuv microbiota yog qhov muaj feem cuam tshuam los yog qhov tshwm sim ntawm kev rog rog tseem muaj teeb meem. Tsis ntev los no randomized soj ntsuam kev sim (RCTs) ntsuam xyuas seb probiotic modulation ntawm plab microbiota pab yuag poob tau muaj kev tsis sib haum xeeb, uas yuav raug ntaus nqi rau heterogeneity nyob rau hauv kev kawm tsim. Lub hom phiaj ntawm tsab xov xwm no yog txhawm rau txheeb xyuas qhov sib txawv ntawm cov kev cuam tshuam thiab kev ntsuas lub cev rog hauv cov kev sim ntsuas randomized ntsuas qhov cuam tshuam ntawm probiotics ntawm lub cev qhov hnyav thiab lub cev rog hauv cov neeg rog rog thiab rog. Peb caug-peb randomized tswj kev sim tau raug txheeb xyuas los ntawm kev tshawb nrhiav lub tswv yim. Raws li cov txiaj ntsig tseem ceeb, cov kws sau ntawv tau pom tias kwv yees li 30 feem pua ntawm RCTs tau tshaj tawm qhov txo qis hauv lub cev hnyav thiab lub cev qhov hnyav (BMI), thiab kwv yees li 50 feem pua ntawm RCTs qhia txog qhov txo qis hauv duav ncig thiab tag nrho cov rog. Cov txiaj ntsig zoo ntawm probiotics tau zoo sib xws hauv 12-ib lub lim tiam sim ntawm koob tshuaj 1010 CFU/d hauv cov tshuaj ntsiav, hnab lossis hmoov uas tsis muaj kev txwv lub zog. Cov ntaub ntawv pov thawj rau cov teebmeem ntawm probiotics ntawm lub cev adiposity tuaj yeem txhim kho thiab ua tau zoo dua nyob rau yav tom ntej randomized tswj kev sim uas suav nrog cov txheej txheem xws li kev siv sijhawm ntev dua, ntau dua, cov tsheb tsis yog mis nyuj, txwv tsis pub lub zog asynchronous thiab kev siv cov kev ntsuas tseeb ntawm lub cev rog. kev tso nyiaj (piv txwv li, lub cev rog thiab lub duav ncig) tsis yog qhov hnyav thiab BMI.
Kev sib raug zoo ntawm Probiotics thiab rog
Ntau cov kev tshawb fawb tau pom qhov muaj nuj nqis thiab zoo hloov pauv hauv microbiota muaj pes tsawg leeg ntawm cov tib neeg rog rog piv nrog cov tib neeg lean, suav nrog kev txo qis hauv microbial ntau haiv neeg. Tsis tas li ntawd, qhov nce ntxiv ntawm Firmicutes rau Bacteroidetes tau nquag pom. Kev tshuaj xyuas tsis ntev los no ntawm 32 cov kev tshawb fawb pom tias cov neeg rog rog muaj qhov sib piv ntau dua ntawm Firmicutes / Bacteroidetes, Firmicutes, Fusobacteria, Proteobacteria, Mollicutes, Lactobacillus (reuteri) siab dua, whereas Akkermansia muciniphila, Faecalibacterium (prauserobacillus, B. thiab Lactobacillus paracasei muaj tsawg dua.
Txawm hais tias cov kev tshawb fawb tau pom tias plab microbiota dysbiosis cuam tshuam nrog kev rog, txawm tias kev hloov pauv hauv plab microbiota ua ntej rog (ua rau) lossis cuam tshuam txog kev rog rog (qhov tshwm sim) tseem muaj teeb meem. Yog li ntawd, lub luag haujlwm ua rau lub plab microbiota nyob rau hauv pathogenesis ntawm kev rog rog tseem muaj teeb meem thiab tseem muaj kev sib cav.
Kev noj zaub mov muaj feem cuam tshuam rau lub plab microbiota. Ntau cov kev tshawb fawb tau pom tias cov as-ham, xws li fiber ntau thiab rog, nrog rau cov khoom noj tshwj xeeb thiab cov qauv kev noj haus tuaj yeem hloov kho plab microbiota muaj pes tsawg leeg thiab ua haujlwm. Piv txwv li, kev noj zaub mov muaj roj ntau thiab cov qauv kev noj qab haus huv Western (tus cwj pwm los ntawm kev noj zaub mov ntau, cov rog saturated, thiab cov suab thaj) cuam tshuam nrog microbiota tsis zoo, thaum noj fiber ntau thiab ua raws li cov qauv noj qab haus huv, xws li kev noj zaub mov Mediterranean, yog txuam nrog plab microbiota cov txiaj ntsig ntawm pab pawg.
Mechanisms txuas Probiotics rau poob phaus
Raws li tau hais los saum no, cov ntaub ntawv qhia txog kev sib raug zoo ntawm plab microbiota thiab tswj qhov hnyav. Cov neeg sib tw cov txheej txheem piav qhia txog lub luag haujlwm tseem ceeb ntawm plab microbiota dysbiosis hauv kev rog rog suav nrog nce lub zog sau los ntawm plab microbiota, nce rog cia hauv cov ntaub so ntswg adipose, txo qis qis ntawm cov tshuaj hormones anaerobic, thiab qib qis qis vim muaj cov plab hnyuv permeability.
Lub plab flora muaj glycosidases thiab lyases uas degrade thiab ferment polysaccharides thiab cov khoom noj uas tsis tuaj yeem zom tau los ntawm tib neeg lub cev rau hauv absorbable monosaccharides thiab (short-chain fatty acids) xws li propionate, butyrate thiab acetate tseem ceeb. Cov kab hluav taws xob luv luv no yog siv los ntawm tus tswv tsev ua lub zog, ua kom lub zog tau los ntawm kev noj haus. Kev rog rog yog txuam nrog cov kab mob uas ferment carbohydrates nyob rau hauv ntau qhov ntau, ua rau cov synthesis ntawm luv-chain fatty acids, uas muab ib tug ntxiv zog substrate rau tus tswv tsev.
Lub plab microbiota plays lub luag haujlwm tseem ceeb hauv kev tswj cov noob muaj feem xyuam nrog cov roj cia. Kev hloov pauv hauv plab microbiota inhibit qhov kev qhia ntawm yoo mov-vim adipokine (FIAF), uas, ntxiv rau nws cov nyhuv inhibitory ntawm lipoprotein lipase, yog lub zog tswj hwm ntawm fatty acid oxidation, ua rau muaj zog triglyceride deposition hauv cov ntaub so ntswg adipose.
Lwm lub peev xwm txheej txheem suav nrog adenosine monophosphate-activated protein kinase (AMPK), ib qho enzyme uas saib xyuas lub zog thiab tswj cov metabolism hauv lub zog. Hauv plab dysbiosis, AMPK yog inhibited, ua rau txo qis fatty acid oxidation thiab nce triglyceride synthesis.
Cov kev tshawb fawb tau pom tias plab hnyuv microbiota-derived luv-chain fatty acids ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev siv hluav taws xob. Ntau qhov kev tshawb fawb tau pom tias SCFAs tuaj yeem txo lub plab motility thiab tswj satiety los ntawm kev cuam tshuam rau kev tsim cov tshuaj satiety xws li glucagon-zoo li peptide 1, peptide YY, thiab leptin.
Lwm txoj hauv kev txuas kev rog rog rau plab microbiota dysbiosis yog plab permeability, tej zaum vim muaj LPS-nqa cov kab mob hauv plab thiab tom qab ua kom cov neeg hu xov tooj zoo li ntawm lub cev tiv thaiv kab mob. Yog li, nrog nce plab permeability, cov kab mob cuam tshuam nrog cov qauv molecular, xws li lipopolysaccharides thiab peptidoglycans (pro-inflammatory molecules ntawm plab microbiota), raug lees paub los ntawm cov tswv tsev receptors, txhawb kev mob ntev.