Probiotics thiab ua xua
Bifidobacterium longum HH-BL18
Kev tsis haum tshuaj yog txuam nrog kev hloov pauv ntawm Th1 / Th2 cytokine tshuav nyiaj li cas rau Th2 teb. Qhov no ua rau kev ua kom Th2 cytokines thiab tso tawm ntawm interleukin-4 (IL-4), IL-5, thiab IL-13 nrog rau kev tsim tawm IgE.
Bifidobacterium longum HH-BL18 tuaj yeem hloov kho cov neeg hu xov tooj zoo li receptors thiab proteoglycan lees paub cov proteins ntawm enterocytes, ua rau ua kom cov hlwb dendritic thiab Th1 teb. Qhov tshwm sim ntawm Th1 cytokines tuaj yeem cuam tshuam Th2 cov lus teb. Nws tseem tuaj yeem txhim kho IFN-tsim thiab txo IgE thiab antigen-induced TN F-, IL-5, thiab IL{10}} secretion.
Bifidobacterium lactis HH-BA68
B. Lactis HH-BA68 tuaj yeem txo cov tsos mob ua xua ntawm cov qauv tsiaj nrog kev ua xua rau zaub mov los ntawm kev txo cov ntshav qab zib ntawm IgE. B. lactis tuaj yeem nce qib mRNA txheeb ze ntawm FoxP3 thiab TGF- thiab txo qhov txheeb ze mRNA qib ntawm IL-17A thiab IL-23. Tag nrho cov cytokines no yog txuam nrog cov theem ntawm Treg thiab Th17 hlwb. Th17 hlwb cuam tshuam nrog pathogenesis ntawm Th2-kev ua xua tsis haum. Th17 hlwb tswj cov neeg ua haujlwm neutrophil thiab ua lub luag haujlwm tseem ceeb hauv kev ua xua. Th17 thiab Treg hlwb ua lub luag haujlwm tseem ceeb hauv cov kab mob atopic. B. lactis HH-BA68 induced ib tug tseem ceeb kam rau ua rau cov tsos mob ntawm kev tsis haum tshuaj los ntawm kev ua kom Treg hlwb sib txawv thiab suppressing Th17- hom hlwb sib txawv. Tsis tas li ntawd, B. lactis tuaj yeem txhawb cov txheej txheem antiallergenic los ntawm induction ntawm Th{14}} hom kev tiv thaiv kab mob thiab txhim kho cov kev tswj hwm lymphocyte.
Lactobacillus reuteri PB-LR09
Kev soj ntsuam ntawm cov chemokines circulating chemokines yog ib qho cuab yeej siv tau los tshawb xyuas T tus pab (Th) 1 / Th2 imbalance nyob rau hauv cov kab mob ua xua thiab lwm yam kab mob hauv vivo. Kev kho Probiotic nrog Lactobacillus reuteri PB-LR09 tau pom tias muaj feem cuam tshuam nrog qis qis ntawm cov tshuaj tiv thaiv kab mob Th2- thiab Th1- cuam tshuam cytokines thaum tseem me nyuam mos, nrog rau qis IL-10 thiab Th2-sociated CCL22 cov lus teb. Ntxiv mus, qis mitogen induced Th2-zoo li cov lus teb kuj tau txuam nrog L. reuteri PB-LR09 supplementation. Qhov qis cytokine thiab chemokine qib hauv pawg probiotic tuaj yeem qhia tias muaj kev tiv thaiv kab mob tiv thaiv kab mob, tej zaum yuav ua rau txo qis atopic propensity.
Lactobacillus rhamnosus PB-LR09
Cow's mis allergy (CMA) yog ib qho kev txhawj xeeb thoob ntiaj teb kev noj qab haus huv uas tshwm sim ntau zaus ntawm cov menyuam yaus dua li cov neeg laus. Hauv peb txoj kev tshawb fawb, peb pom tias qhov ncauj L.rhamnosus PB-LR76 kev tswj hwm tuaj yeem pab txo lossis tswj CMA hauv Balb/C nas uas tau hnov qab nrog nyuj cov kua mis protein (CMP) los ntawm qhov ncauj (gavage) lossis txoj hauv kev (IP). Kev tswj qhov ncauj ntawm L.rhamnosus PB-LR76 tej zaum yuav txo tau qhov tsis haum tshuaj raws li qhia los ntawm cov lus teb txo qis qis, qis Il-4 qib, thiab qis CMP-specific IgG1 tab sis siab dua IFN- thiab CMP-specific IgG2a qib. Feem ntau, qhov nce ntawm Th2 cov lus teb hauv cov nas ua rau muaj kev zais ntau dua ntawm IL-4, thiab cov tshuaj tsis haum rau IgE thiab IgG1, qhov nce Th1 cov lus teb ua rau ntau dua IFN- thiab IgG2a. Yog li ntawd, peb qhov kev tshawb pom qhia tias L.rhamnosus PB-LR76 supplementation tuaj yeem txo cov kev tsis haum tshuaj los ntawm kev cuam tshuam Th2- cov lus teb hauv lub cev.
Lactobacillus paracasei HH-LP58
Lub pathogenesis ntawm kev tsis haum tshuaj yog piav raws li qhov tsis txaus ntawm Th1 / Th2 hlwb. Lactobacillus paracasei HH-LP58 inhibits cov kab mob ua xua los ntawm inhibiting Th2 teb. Interleukin (IL)-4, IL-5, thiab IL-13 yog cov sawv cev cytokines tso tawm los ntawm Th2 hlwb uas raug txwv los ntawm Lactobacillus paracasei HH-LP58. Tsis tas li ntawd, Lactobacillus paracasei HH-LP58 nce IL-10 thiab qog kev loj hlob (TGF) - theem los ntawm inducing Tregs hlwb hauv cov kab mob ua xua.